1.A.9.5.15
Gamma-aminobutyric acid receptor subunit alpha-5, GABRA5, of 462 aas and 4 TMSs in a 3 + 1 C-terminal arrangement. It is a ligand-gated chloride channel subunit which is a component of the
heteropentameric receptor for GABA, the major inhibitory
neurotransmitter in the brain (Butler et al. 2018, Hernandez et al. 2019). It may be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse (Hernandez et al. 2019). Ablation of Gabra5 influences corticosterone levels and anxiety-like behavior in mice (Syding et al. 2023).
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| Accession Number: | P31644 |
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| Protein Name: | Gamma-aminobutyric acid receptor subunit alpha-5 |
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| Length: | 462 |
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| Molecular Weight: | 52146.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Postsynaptic cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
chloride |
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1: MDNGMFSGFI MIKNLLLFCI SMNLSSHFGF SQMPTSSVKD ETNDNITIFT RILDGLLDGY
61: DNRLRPGLGE RITQVRTDIY VTSFGPVSDT EMEYTIDVFF RQSWKDERLR FKGPMQRLPL
121: NNLLASKIWT PDTFFHNGKK SIAHNMTTPN KLLRLEDDGT LLYTMRLTIS AECPMQLEDF
181: PMDAHACPLK FGSYAYPNSE VVYVWTNGST KSVVVAEDGS RLNQYHLMGQ TVGTENISTS
241: TGEYTIMTAH FHLKRKIGYF VIQTYLPCIM TVILSQVSFW LNRESVPART VFGVTTVLTM
301: TTLSISARNS LPKVAYATAM DWFIAVCYAF VFSALIEFAT VNYFTKRGWA WDGKKALEAA
361: KIKKKREVIL NKSTNAFTTG KMSHPPNIPK EQTPAGTSNT TSVSVKPSEE KTSESKKTYN
421: SISKIDKMSR IVFPVLFGTF NLVYWATYLN REPVIKGAAS PK