1.A.9.5.9 GabaA1 receptor of 459 aas and 4 TMSs. 87% identical to the human homologue (TC# 1.A.9.5.4). Insecticides, abamectin, dieldrin, fluralaner and fipronil strongly inhibited GABA-induced inward current >50% at 10-6 M, while alpha-endosulfan, flufiprole and ethiprole inhibited <50% (Huang et al. 2018). Flumazenil-insensitive benzodiazepine binding sites in GABAA receptors contribute to benzodiazepine-induced immobility in zebrafish larvae (Cao et al. 2019). Delta selective compound 2 (DS2; 4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide) is widely used to study selective actions mediated by delta-subunit-containing GABAA receptors. The molecular determinants responsible for positive modulation by DS2 have been identified (Falk-Petersen et al. 2021).
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Accession Number: | Q08BJ3 |
Protein Name: | Gabra1 protein |
Length: | 459 |
Molecular Weight: | 51645.00 |
Species: | Danio rerio (Zebrafish) [7955] |
Number of TMSs: | 4 |
Substrate |
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1: MMWGGRGAAW LWIWACLLVT NALAGKSSSQ NADEQKDNTT VFTRILDSLL DGYDNRLRPG
61: LGERVTEVKT DIFVTSIGPV SDHDMEYTID VFFRQSWKDE RLKFKGPMAV LRLNNLMASK
121: IWTPDTFFHN GKKSVAHNMT MPNKLLRITE EGTLLYTMRL TVRAECPMHL EDFPMDAHAC
181: PLKFGSYAYT RAEVVYVWTR GAAQSVVVAD DGSRLNQYDL MGQSVDSGVV QSSTGEYVVM
241: TTHFHLKRKI GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA
301: RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GYAWDGKSVV PEKQKKKKES
361: LLKKNNTYTA ATATAFAPNI ARDPGLATIA KSAPPPPTEP KEEPKPKPPE AKKTFNSVSK
421: IDRIARIAFP LLFGTFNLVY WATYLNKKPK LQGMNLQPH