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1.A.9.5.9
GabaA1 receptor of 459 aas and 4 TMSs.  87% identical to the human homologue (TC# 1.A.9.5.4). Insecticides, abamectin, dieldrin, fluralaner and fipronil strongly inhibited GABA-induced inward current >50% at 10-6 M, while alpha-endosulfan, flufiprole and ethiprole inhibited <50% (Huang et al. 2018). Flumazenil-insensitive benzodiazepine binding sites in GABAA receptors contribute to benzodiazepine-induced immobility in zebrafish larvae (Cao et al. 2019). Delta selective compound 2 (DS2; 4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide) is widely used to study selective actions mediated by delta-subunit-containing GABAA receptors. The molecular determinants responsible for positive modulation by DS2 have been identified (Falk-Petersen et al. 2021).

Accession Number:Q08BJ3
Protein Name:Gabra1 protein
Length:459
Molecular Weight:51645.00
Species:Danio rerio (Zebrafish) [7955]
Number of TMSs:4
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMWGGRGAAW LWIWACLLVT NALAGKSSSQ NADEQKDNTT VFTRILDSLL DGYDNRLRPG 
61:	LGERVTEVKT DIFVTSIGPV SDHDMEYTID VFFRQSWKDE RLKFKGPMAV LRLNNLMASK 
121:	IWTPDTFFHN GKKSVAHNMT MPNKLLRITE EGTLLYTMRL TVRAECPMHL EDFPMDAHAC 
181:	PLKFGSYAYT RAEVVYVWTR GAAQSVVVAD DGSRLNQYDL MGQSVDSGVV QSSTGEYVVM 
241:	TTHFHLKRKI GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA 
301:	RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GYAWDGKSVV PEKQKKKKES 
361:	LLKKNNTYTA ATATAFAPNI ARDPGLATIA KSAPPPPTEP KEEPKPKPPE AKKTFNSVSK 
421:	IDRIARIAFP LLFGTFNLVY WATYLNKKPK LQGMNLQPH