1.A.97.1.1
The E5 viroporin protein of 83 aas and 3 TMSs (Wetherill et al. 2012). It forms hexameric channels with TMS2 lining the pore, creating a water column through which ions and small molecules, including H⁺, can pass fairly non-specifically (Mahato and Fischer 2016). A "snapshot" structure of the putative open pore of the protein bundle suggested the proposed low channel selectivity (Mahato and Fischer 2016). The protein is involved in signalling and protein trafficking. Its gene may be an oncogene (Scott and Griffin 2015).The protein also interacts with the fourth TMS of the 16 kDa c subunit of the human vacuolar H⁺-ATPase (Mahato and Fischer 2018).