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|---|---|
| Accession Number: | P75780 |
| Protein Name: | Ferric iron uptake protein aka Fiu |
| Length: | 760 |
| Molecular Weight: | 81960.00 |
| Species: | Escherichia coli (strain K12) [83333] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Cell outer membrane1 |
| Substrate | dihydroxybenzoate |
Cross database links:
| DIP: | DIP-11432N |
|---|---|
| RefSeq: | AP_001436.1 NP_415326.1 |
| Entrez Gene ID: | 946246 |
| Pfam: | PF07715 PF00593 |
| BioCyc: | EcoCyc:G6414-MONOMER ECOL168927:B0805-MONOMER |
| KEGG: | ecj:JW0790 eco:b0805 |
Gene Ontology
GO:0009279
C:cell outer membrane
GO:0005886
C:plasma membrane
GO:0005506
F:iron ion binding
GO:0004872
F:receptor activity
GO:0015343
F:siderophore-iron transmembrane transporter ...
GO:0006826
P:iron ion transport
GO:0015891
P:siderophore transport
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References (11)[1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.” Oshima T.et.al. 8905232 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [4] “Iron-regulated outer membrane proteins of Escherichia coli K-12 and mechanism of action of catechol-substituted cephalosporins.” Curtis N.A.C.et.al. 3072926 [5] “Dihydroxybenzoylserine -- a siderophore for E. coli.” Hantke K.et.al. 2139424 [6] “Cir and Fiu proteins in the outer membrane of Escherichia coli catalyze transport of monomeric catechols: study with beta-lactam antibiotics containing catechol and analogous groups.” Nikaido H.et.al. 2407721 [7] “Iron content and FNR-dependent gene regulation in Escherichia coli.” Niehaus F.et.al. 1804764 [8] “Differential fiu-lacZ fusion regulation linked to Escherichia coli colony development.” Newman D.L.et.al. 10411720 [9] “Proteomic analysis of the Escherichia coli outer membrane.” Molloy M.P.et.al. 10806384 [10] “The colicin G, H and X determinants encode microcins M and H47, which might utilize the catecholate siderophore receptors FepA, Cir, Fiu and IroN.” Patzer S.I.et.al. 12949180 [11] “Parasitism of iron-siderophore receptors of Escherichia coli by the siderophore-peptide microcin E492m and its unmodified counterpart.” Destoumieux-Garzon D.et.al. 16718603
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| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MENNRNFPAR QFHSLTFFAG LCIGITPVAQ ALAAEGQTNA DDTLVVEAST PSLYAPQQSA 61: DPKFSRPVAD TTRTMTVISE QVIKDQGATN LTDALKNVPG VGAFFAGENG NSTTGDAIYM 121: RGADTSNSIY IDGIRDIGSV SRDTFNTEQV EVIKGPSGTD YGRSAPTGSI NMISKQPRND 181: SGIDASASIG SAWFRRGTLD VNQVIGDTTA VRLNVMGEKT HDAGRDKVKN ERYGVAPSVA 241: FGLGTANRLY LNYLHVTQHN TPDGGIPTIG LPGYSAPSAG TAALNHSGKV DTHNFYGTDS 301: DYDDSTTDTA TMRFEHDIND NTTIRNTTRW SRVKQDYLMT AIMGGASNIT QPTSDVNSWT 361: WSRTANTKDV SNKILTNQTN LTSTFYTGSI GHDVSTGVEF TRETQTNYGV NPVTLPAVNI 421: YHPDSSIHPG GLTRNGANAN GQTDTFAIYA FDTLQITRDF ELNGGIRLDN YHTEYDSATA 481: CGGSGRGAIT CPTGVAKGSP VTTVDTAKSG NLMNWKAGAL YHLTENGNVY INYAVSQQPP 541: GGNNFALAQS GSGNSANRTD FKPQKANTSE IGTKWQVLDK RLLLTAALFR TDIENEVEQN 601: DDGTYSQYGK KRVEGYEISV AGNITPAWQV IGGYTQQKAT IKNGKDVAQD GSSSLPYTPE 661: HAFTLWSQYQ ATDDISVGAG ARYIGSMHKG SDGAVGTPAF TEGYWVADAK LGYRVNRNLD 721: FQLNVYNLFD TDYVASINKS GYRYHPGEPR TFLLTANMHF