1.B.20.1.3
Outer membrane transporter essential for contact-dependent growth inhibition, CdiB, of 588 aas and possibly two TMSs, one N-terminal and one near the C-terminus (Q3YL97). It exports the protein toxin, CdiA (AAZ57198) (Aoki et al., 2005). It mediates contact-dependent growth inhibition (CDI), a phenomenon by which
bacterial cell growth is regulated by direct cell-to-cell contact. The CdiA/CdiB two-partner secretion system appears to play a direct role (Aoki et al. 2008). The 3-d structure of this secretion system and one other have been determined (Guerin et al. 2020).
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| Accession Number: | Q3YL97 |
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| Protein Name: | CdiB |
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| Length: | 588 |
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| Molecular Weight: | 64522.00 |
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| Species: | Escherichia coli [562] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell outer membrane1 |
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| Substrate |
protein polypeptide chain |
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| Pfam: |
PF08479
PF03865
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[1] “Contact-dependent inhibition of growth in Escherichia coli.” Aoki S.K. et.al. 16109881
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1: MRHRQDNLLA NRTLLPGMAS GQYVFRLCTF SPVVRYFSLL PCLCILSFSS PAAMLSPGDR
61: SAIQQQQQQL LDENQRQRDA LERSAPLTIT PSPETSAGTE GPCFTVSSIV VSGATRLTSA
121: ETDRLVAPWV NQCLNITGLT AVTDAMTDSY IRRGYITSRA FLTEQDLSGG VLHITVMEGR
181: LQQIRAEGAD LPARTLKMVF PGMEGKVLNL RDIEQGMEQI NRLRTEPVQI EISPGDREGW
241: SVVTLTALPE WPVTGSVGID NSGQKSTGTG QLNGVLSFNN PLGLADNWFV SGGRSSDFSV
301: SHDARNFAAG VSLPYGYTLV DYTYSWSDYL STIDNRGWRW RSTGDLQTHR LGLSHVLFRN
361: GDMKTALTGG LQHRIIHNYL DDVLLQGSSR KLTSFSVGLN HTHKFLGGVG TLNPVFTRGM
421: PWFGAESDHG KRGDLPVNQF RKWSVSASFQ RPVTDRVWWL TSAYAQWSPD RLHGVEQLSL
481: GGESSVRGFK DQYISGNNGG YLRNELSWSL FSLPYVGTVR AVAALDGGWL HSDSDDPYSS
541: GTLWGAAAGL STTSGHVSGS FTAGLPLVYP DWLAPDHLTV YWRVAVAF