1.B.20.3.2
HMW1B outer membrane exporter, required for secretion of HMW1A and HMW2A adhesins (exhibit a twin pore dimeric structure) (Li et al., 2007) and forms a large-conductance channel (Duret et al., 2008). The protein has a modular three domain structure: an N-terminal membrane domain, a central periplasmic domain and a C-terminal membrane anchor domain that oligomerizes and forms a pore (Surana et al. 2006). The periplasmic domain is required for secretion.
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| Accession Number: | Q4QJR3 |
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| Protein Name: | HMW1B |
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| Length: | 545 |
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| Molecular Weight: | 60699.00 |
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| Species: | Haemophilus influenzae (strain 86-028NP) [281310] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell junction1 / Multi-pass membrane protein2 |
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| Substrate |
protein polypeptide chain |
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1: MKNIKSRLKL SAISVLLGLA SSSLYAEEAF LVKGFQLSGA LETLSEDAQL SVAKSLSKYQ
61: GTQTLTNLKT AQLELQAVLD KIEPNKFDVI LPQQTITDGN IMFELVSKSA AESQVFYKAS
121: QGYSEENIAR SLPSLKQGKV YEDGRQWFDL REFNMAKENP LKVTRVHYEL NPKNKTSNLI
181: IAGFSPFGKT RSFISYDNFG AREFNYQRVS LGFVNANLTG HDDVLNLNAL TNVKAPSKSY
241: AVGVGYTYPF YSKHQSLSLY TSMSYADSND IDGLPSAINR KLSKGQSISA NLKWSYYLPT
301: FNLGMEDQFK INLGYNYRHI NQTSELNTLG ATKKKFAVSG VSAGIDGHIQ FTPKTIFNID
361: LTHHYYASKL PGSFGMERIG ETFNRSYHIS TASLGLSQEF AQGWHFSSQL SGQFTLQDIS
421: SIDLFSVTGT YGVRGFKYGG ASGERGLVWR NELSMPKYTR FQISPYAFYD AGQFRYNSEN
481: AKIYGEDMHT VSSAGLGIKT SPTQNLSLDA FVARRFANAN SDNLNGNKKR TSSPTTFWGR
541: LTFSF