1.B.25.1.13
Chitoporin, ChiP or YbfM of 468 aas. Takes up chitosugars such as chitobiose. It also plays a role in carbapenem (imipenem) resistance. The orthologue in Proteus mirabilis is ImpR, and that in Salmonella species is YbfM. It is subject to regulation by the small RNA, MicM (Tsai et al. 2015). Loss of OmpC and OmpF results in poor growth, by expression of chiP restores growth (Knopp and Andersson 2015).
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| Accession Number: | P75733 |
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| Protein Name: | Uncharacterized protein ybfM |
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| Length: | 468 |
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| Molecular Weight: | 52780.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Number of TMSs: | 1 |
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| Substrate |
2-(Biaryl)carbapenems |
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| Entrez Gene ID: |
945296
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| Pfam: |
PF03573
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| KEGG: |
ecj:JW0667
eco:b0681
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[1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.” Oshima T. et.al. 8905232
[2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R. et.al. 9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K. et.al. 16738553
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1: MRTFSGKRST LALAIAGVTA MSGFMAMPEA RAEGFIDDST LTGGIYYWQR ERDRKDVTDG
61: DKYKTNLSHS TWNANLDFQS GYAADMFGLD IAAFTAIEMA ENGDSSHPNE IAFSKSNKAY
121: DEDWSGDKSG ISLYKAAAKF KYGPVWARAG YIQPTGQTLL APHWSFMPGT YQGAEAGANF
181: DYGDAGALSF SYMWTNEYKA PWHLEMDEFY QNDKTTKVDY LHSFGAKYDF KNNFVLEAAF
241: GQAEGYIDQY FAKASYKFDI AGSPLTTSYQ FYGTRDKVDD RSVNDLYDGT AWLQALTFGY
301: RAADVVDLRL EGTWVKADGQ QGYFLQRMTP TYASSNGRLD IWWDNRSDFN ANGEKAVFFG
361: AMYDLKNWNL PGFAIGASYV YAWDAKPATW QSNPDAYYDK NRTIEESAYS LDAVYTIQDG
421: RAKGTMFKLH FTEYDNHSDI PSWGGGYGNI FQDERDVKFM VIAPFTIF