TCDB is operated by the Saier Lab Bioinformatics Group

1.B.31 The Campylobacter jejuni Major Outer Membrane Porin (MomP) Family

Campylobacter jejuni MomP is a trimeric, β -sheet-type porin of 424 aas that packs with different lattice types when reconstituted with lipids. The protein can exist as the native trimer or as a stable monomer, depending in the concentration of sodium dodecyl sulfate. It serves several physiological functions: (1) in the structural organization of the outer membrane, (2) as an adhesin, and (3) as a porin. The monomeric and trimeric porins exhibit similar single channel conductances with the same cation selectivities and the same sensitivities to voltage when reconstituted in an artificial lipid bilayer. A second homologue of MomP with 88% identity to the first one has been sequenced (gbAL139077).

The transport reaction catalyzed by the C. jejuni MomP is:

solutes (out) solutes (periplasm)

References associated with 1.B.31 family:

Bolla, J.M., N. Saint, G. Labesse, J.M. Pagès, and C. Dumas. (2004). Crystallization and preliminary crystallographic studies of MOMP (major outer membrane protein) from Campylobacter jejuni. Acta Crystallogr D Biol Crystallogr 60: 2349-2351. 15583387
Dé, E., M. Jullien, G. Labesse, J.M. Pagès, G. Molle, and J.M. Bolla. (2000). MOMP (major outer membrane protein) of Campylobacter jejuni; a versatile pore-forming protein. FEBS Lett. 469: 93-97. 10708763
Dhanasekar, N.N., S. Aliouane, M. Winterhalter, J.M. Pagès, and J.M. Bolla. (2017). Peptide translocation across MOMP, the major outer membrane channel from Campylobacter jejuni. Biochem Biophys Rep 11: 79-83. 28955771
Mohan, V. and I. Habib. (2019). Multilocus sequence typing (MLST), porA and flaA typing of Campylobacter jejuni isolated from cats attending a veterinary clinic. BMC Res Notes 12: 76. 30717780
Vanmarsenille, C., I. Díaz Del Olmo, J. Elseviers, G. Hassanzadeh Ghassabeh, K. Moonens, D. Vertommen, A. Martel, F. Haesebrouck, F. Pasmans, J.P. Hernalsteens, and H. De Greve. (2017). Nanobodies targeting conserved epitopes on the major outer membrane protein of Campylobacter as potential tools for control of Campylobacter colonization. Vet Res 48: 86. 29216932
Zhuang, J., A. Engel, J-M. Pages, and J.M. Bolla (1997). The Campylobacter jejuni porin trimers pack into different lattice types when reconstituted in the presence of lipid. Eur. J. Biochem. 244: 575-579. 9119026