1.B.33.3.4
Sam50 (SAMM50, CGI-51, TRG3) of 469 aas. Höhr et al. 2018
mapped the interaction of a precursor in transit with the mitochondrial
Omp85-channel, Sam50, in the native membrane environment. The precursor
translocates into the channel interior, interacts with an internal
loop, and inserts into the lateral gate by β-signal exchange. Transport
through the Omp85-channel interior followed by release through the
lateral gate into the lipid phase represents a basic mechanism for
membrane insertion of β-barrel proteins (Höhr et al. 2018). PNPLA3, TM6SF2 (TC# 8.A.93.2.1) and SAMM50 are associated with the development and severity of pediatric non-alcoholic fatty liver disease (NAFLD) (Lee et al. 2022).
|
| Accession Number: | Q9Y512 |
|---|
| Protein Name: | Sorting and assembly machinery component 50 homolog |
|---|
| Length: | 469 |
|---|
| Molecular Weight: | 51976.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Location1 / Topology2 / Orientation3: |
Mitochondrion outer membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
protein polypeptide chain |
|---|
1: MGTVHARSLE PLPSSGPDFG GLGEEAEFVE VEPEAKQEIL ENKDVVVQHV HFDGLGRTKD
61: DIIICEIGDV FKAKNLIEVM RKSHEAREKL LRLGIFRQVD VLIDTCQGDD ALPNGLDVTF
121: EVTELRRLTG SYNTMVGNNE GSMVLGLKLP NLLGRAEKVT FQFSYGTKET SYGLSFFKPR
181: PGNFERNFSV NLYKVTGQFP WSSLRETDRG MSAEYSFPIW KTSHTVKWEG VWRELGCLSR
241: TASFAVRKES GHSLKSSLSH AMVIDSRNSS ILPRRGALLK VNQELAGYTG GDVSFIKEDF
301: ELQLNKQLIF DSVFSASFWG GMLVPIGDKP SSIADRFYLG GPTSIRGFSM HSIGPQSEGD
361: YLGGEAYWAG GLHLYTPLPF RPGQGGFGEL FRTHFFLNAG NLCNLNYGEG PKAHIRKLAE
421: CIRWSYGAGI VLRLGNIARL ELNYCVPMGV QTGDRICDGV QFGAGIRFL