1.B.36.1.1
The p13 porin (Ostberg et al. 2002). P13 displays a general (non-specific) channel-forming activity
of 0.6 nanosiemens in 1 m KCl, has no preference for either cations
or anions and shows no voltage-gating up to ±100 mV. The native P13 protein complex has a high
molecular mass of about 300 kDa and is composed only of P13 monomers.
The channel diameter was estimated to be about 1.4 nm with a 400-Da molecular mass cut-off (Bárcena-Uribarri et al. 2014).
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| Accession Number: | Q7BSC0 |
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| Protein Name: | Membrane protein P13 |
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| Length: | 179 |
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| Molecular Weight: | 19104.00 |
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| Species: | [139] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
molecule |
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| RefSeq: |
NP_212168.1
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| Entrez Gene ID: |
1194870
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| Pfam: |
PF05628
|
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| BioCyc: |
BBUR224326:BB_0034-MONOMER
|
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| KEGG: |
bbu:BB0034
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[1] “P13, an integral membrane protein of Borrelia burgdorferi, is C-terminally processed and contains surface-exposed domains.” Noppa L. et.al. 11292755
[2] “Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.” Fraser C.M. et.al. 9403685
[3] “Molecular analysis of the channel-forming protein P13 and its paralogue family 48 from different Lyme disease Borrelia species.” Pinne M. et.al. 14993304
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1: MNKLLIFVLA TFCVFSSFAQ ANDSKNGAFG MSAGEKLLVY ETSKQDPIVP FLLNLFLGFG
61: IGSFAQGDIL GGSLILGFDA VGIGLILAGA YLDIKALDGI TKKAAFQWTW GKGVMLAGVV
121: TMAVTRLTEI ILPFTFANSY NRKLKNSLNV ALGGFEPSFD VAMGQSSALG FELSFKKSY