1.B.51.1.1
Outer membrane-spanning porin, Oms66 (P66) (Skare et al., 1997). This porin has a β-barrel structure (Kenedy et al. 2013) and pore diameters at the mouth of 1.6nm and at the central constriction of 0.8nm (Bárcena-Uribarri et al. 2013). Oms66 plays a role in resistance to host immune defenses (Curtis et al. 2018). The contribution of P66 porin function to B. burgdorferi pathogenesis has been evaluated (Fierros et al. 2024).
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| Accession Number: | Q44881 |
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| Protein Name: | Oms66 |
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| Length: | 618 |
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| Molecular Weight: | 68172.00 |
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| Species: | Borrelia burgdorferi (Lyme disease spirochete) [139] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
molecule |
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1: MKSHILYKLI IFLTTSAAIF AADALKEKDI FKINPWMPTF GFENTSEFRL DMDELVPGFE
61: NKSKITIKLK PFEANPELGK DDPFSAYIKV EDLALKAEGK KGDQFKIDVG DITAQINMYD
121: FFIKISTMTD FDFNKESLFS FAPMTGFKST YYGFPSNDRA VRGTILARGT SKNIGTIQLG
181: YKLPKLDLTF AIGGTGTGNR NQENDKDTPY NKTYQGILYG IQATWKPIKN LLDQNEDTKS
241: VIAETPFELN FGLSGAYGNE TFNNSSITYS LKDKSVVGND LLSPTLSNSA ILASFGAKYK
301: LGLTKINDKN TYLILQMGTD FGIDPFASDF SIFGHISKAA NFKKETPSDP NKKAEIFDPN
361: GNALNFSKNT ELGIAFSTGA SIGFAWNKDT GEKESWAIKG SDSYSTRLFG EQDKKSGVAL
421: GISYGQNLYR SKDTEKRLKT ISENAFQSLN VEISSYEDNK KGIINGLGWI TSIGLYDILR
481: QKSVENYPTT ISSTTENNQT EQSSTSTKTT TPNLTFEDAM KLGLALYLDY AIPIASISTE
541: AYVVPYIGAY ILGPSNKLSS DATKIYLKTG LSLEKLIRFT TISLGWDSNN IIELANKNTN
601: NAAIGSAFLQ FKIAYSGS