TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
1.B.6.1.1 | Weakly anion-selective OmpA porin. Can exist in two distinct conductance states (Arora et al. 2000). May function in the transport of phenylpropanoids (resveratrol, naringenin and rutin) (Zhou et al. 2014). Three membrane-bound folding intermediates of OmpA were discovered in folding studies with dioleoylphosphatidylcholine bilayers. A highly synchronized mechanism of secondary and tertiary structure formation, applicable to this and other β-barrel membrane proteins has been described (Kleinschmidt 2006). | Bacteria |
Pseudomonadota | OmpA of E. coli (P0A910) |
1.B.6.1.2 | OmpF (OprF) porin. The N-terminal domain has pore activity (Saint et al. 2000). The protein can exist in multiple conformations of variable conductivities (Nestorovich et al. 2006). Factors affecting its one-domain open conformer have been studied by Sugawara et al. (2010). OprF is a complement component C3 receptor (Mishra et al. 2015) and is a target of antibacterial drugs (Maccarini et al. 2017). OprF assumes dual conformations and is involved in solute transport, cell envelope integrity, biofilm formation and pathogenesis (Cassin and Tseng 2019). OprF in Pseudomonas aeruginosa is involved in biofilm stimulation by subinhibitory antibiotics (Yaeger et al. 2024). | Bacteria |
Pseudomonadota | OmpF (OprF) of Pseudomonas aeruginosa (P13794) |
1.B.6.1.3 | OmpATb (ArfA). The central domain (residues 73-220) has been reported to exhibit channel activity (Molle et al., 2006). Its expression is dependent on small single TMS membrane proteins which are encoded in a single operon with it (Veyron-Churlet et al., 2011). The rv0899 gene, encoding OmpATb, is part of an operon (rv0899-rv0901) that is required for fast ammonia secretion, pH neutralization, and growth of M. tuberculosis in acidic environments (Song et al. 2011). Homologues are widespread in bacteria with functions in nitrogen metabolism, adaptation to nutrient poor environments, and/or establishing symbiosis with host organisms (Marassi, 2011). The high resolution 3-d structure is known, revealing two independent domains separated by a proline-rich hinge region.The C-terminal domain (OmpATb(198-326)) revealed a module structurally related to other OmpA-like proteins from Gram-negative bacteria, but the N-terminal domain(73-204), which forms channels in planar lipid bilayers, exhibits a fold, which belongs to the α+β sandwich class fold. It exists in a major monomeric form and a minor oligomeric form yielding rings able to insert into phospholipid membranes (Yang et al. 2011). | Bacteria |
Actinomycetota | OmpATb of Mycobacterium tuberculosis (P65593) |
1.B.6.1.4 | HMP-AB outer membrane porin, OmpAb or Omp38 (Gribun et al., 2004). It is the principle porin with an inner diameter of 2 nm which allows transport of cephalothin, cephaloridine, other antibiotics as well as other small molecules across the outer membrane (Sugawara and Nikaido 2012). Structural studies have been reported (Vashist and Rajeswari 2006). It is a secreted emulifier in some strains of Acinetobacter (Walzer et al. 2006). The sequence provided may be slightly incorrect (see the Q6BYW5 sequence of 356 aas). | Bacteria |
Pseudomonadota | HMP-AB of Acinetobacter baumannii (Q8KWW6) |
1.B.6.1.5 | The OmpA-OmpF porin (OOP) family member, GmpA (involved in acetic acid fermentation; under quorum sensing control) (Iida et al., 2008). (most similar to 1.B.6.1.4) | Bacteria |
Pseudomonadota | GmpA of Gluconacetobacter intermedius (B3A000) |
1.B.6.1.6 | Outer membrane protein 40 (Omp40) (PG33) | Bacteria |
Bacteroidota | PG_0694 of Porphyromonas gingivalis |
1.B.6.1.7 | OmpA homologue | Bacteria |
Bacillota | OmpA homologue of Megasphaera elsdenii |
1.B.6.1.8 | OmpA homologue | Bacteria |
Bacillota | OmpA homologue of Megasphaera sp. UPII 135-E |
1.B.6.1.9 | OMP_b-br1 family protein | Bacteria |
Bacillota | Outer membrane protein of Megasphaera elsdenii |
1.B.6.1.10 | Outer membrane insertion signal domain protein of 190 aas and one N-terminal TMS. An ortholog in Veillonella parvula is 84% identical, and was considered to be a porin by Poppleton et al. 2017. | Bacteria |
Bacillota | OMISD protein of Veillonella atypica |
1.B.6.1.11 | OmpA of 210 aas. The 3-d structure has been solved by NMR (Renault et al. 2010), and its dynamics have been examined (Renault et al. 2009). | Bacteria |
Pseudomonadota | OmpA of Klebsiella pneumoniae |
1.B.6.1.12 | Omp34 outer membrane porin of 346 aas. Also known as the Major antigen Fc binding protein (White et al. 1998). | Bacteria |
Pseudomonadota | Omp34 of Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) |
1.B.6.1.13 | Putative porin of 253 aas | Bacteria |
Actinomycetota | Putative porin of Nocardioidaceae bacterium Broad-1 |
1.B.6.1.14 | Outer membrane protein of 638 aas, OmpF | Bacteria |
Bacteroidota | OmpF of Cecembia lonarensis |
1.B.6.1.15 | OmpA/F | Bacteria |
Spirochaetota | OmpA/F of Treponema pallidum |
1.B.6.1.16 | OmpA family porin of 410 aas | Bacteria |
Pseudomonadota | OmpA porin of Phenylobacterium zucineum |
1.B.6.1.17 | Putative OmpF homologue | Bacteria |
Spirochaetota | Putative OmpF homologue of Leptospira interrogans |
1.B.6.1.18 | Outer membrane protein of 210 aas and 8 putative TMSs | Bacteria |
Pseudomonadota | OMP of Thiothrix nivea |
1.B.6.1.19 | Outer membrane protein of 218 aas and 8 putative TMSs | Bacteria |
Bacteroidota | OMP of Mariniradius saccharolyticus |
1.B.6.1.20 | OmpA homologue of 189 aas | Bacteria |
Spirochaetota | OmpA homologue of Leptospira biflexa |
1.B.6.1.21 | OmpA-type porin of 160 aas, YfiB The yfiRNB locus in E. coli CFT073 contains genes for YfiN, a diguanylate cyclase, and its activity regulators, YfiR and YfiB.(Raterman et al. 2013). | Bacteria |
Pseudomonadota | YfiB of E. coli |
1.B.6.1.22 | Constitutively expressed OmpA of 365 aas (Gao et al. 2015). | Bacteria |
Pseudomonadota | OmpA of Shewanella oneidensis |
1.B.6.1.23 | OmpA of 354 aas with 1 N-terminal α-TMS, 10 putative β-TM Strands and a periplasmic C-terminal domain, probably a peptidoglycan-binding domain (Khalid et al. 2008). Plays a role in virulence (pneumonia in pigs and ruminants) (Verma et al. 2016; Confer and Ayalew 2013) and has been used for vaccine development (Dabo et al. 2008). | Bacteria |
Pseudomonadota | OmpA of Pasteurella multocida |
1.B.6.1.24 | Omp38; OmpA of 356 aas and 1 N-terminal TMSs. It is a selective antibiotic transporting porin (Iyer et al. 2018; Jyothisri et al. 1999) and induces apoptosis in human cell lines through caspase-dependent and
AIF-dependent pathways. Purified Omp38 enters host cells and localizes to
the mitochondria, which presumably leads to a release of proapoptotic
molecules such as cytochrome c and AIF (apoptosis-inducing factor)
(Choi et al. 2005). It is a virulence factor (Scribano et al. 2024). | Bacteria |
Pseudomonadota | omp38 of Acinetobacter baumannii |
1.B.6.1.25 | Putative OmpA porin of 345 aas and one N-terminal TMS. Its gene is adjacent to an autoinducer exporter-like protein (2.A.86.1.11) (Poppleton et al. 2017). | Bacteria |
Bacillota | OmpA-like protein of Veillonella parvula |
1.B.6.1.26 | OmpA -like protein of 159 aas and 1 N-terminal TMS, PsaB or YfiB. It is involved in stress tolerance (Scribano et al. 2024). | Bacteria |
Pseudomonadota | PsaB of Acinetobacter baumannii |
1.B.6.2.1 | Outer membrane porin precursor, OmpX (8 TM β-strands). The NMR structures in lipid bilayers has been solved (Mahalakshmi et al., 2007; Mahalakshmi and Marassi, 2008; Fernández et al. 2004). Expression of the encoding gene is induced by acid or base compared to pH 7 (Stancik et al. 2002). | Bacteria |
Pseudomonadota | OmpX of E. coli (P0A917) |
1.B.6.2.2 | The attachment inversion locus (Ail) (Bartra et al., 2007). Membrane-bound proteins, Ail and OmpF, are involved in the adsorption of T7-related bacteriophage (Zhao et al. 2013). | Bacteria |
Pseudomonadota | Ail of Yersinia pestis (Q0WCZ9) |
1.B.6.2.3 | Opacity family porin protein | Bacteria |
Pseudomonadota | UMN179_00549 of Gallibacterium anatis |
1.B.6.2.4 | Opacity family porin protein | Bacteria |
Pseudomonadota | UMN179_00948 of Gallibacterium anatis |
1.B.6.2.5 | Neisserial surface protein A, NspA of 174 aas and 8 TMSs (Hou et al. 2003). | Bacteria |
Pseudomonadota | NspA of Neisseria meningitidis |
1.B.6.2.6 | Porin opacity type | Bacteria |
Pseudomonadota | AM202_02155 of Actinobacillus minor 202 |
1.B.6.2.7 | Outer membrane porin homolog, but annotated as arginine transporter permease subunit, ArtM, in Uniprot. | Bacteria |
Pseudomonadota | GGC_0882 of Haemophilus haemolyticus M21621 |
1.B.6.2.8 | Opa-like protein A | Bacteria |
Pseudomonadota | E9U_09445 of Moraxella catarrhalis BC8 |
1.B.6.2.9 | Surface protein A | Bacteria |
Pseudomonadota | NspA of Neisseria wadsworthii 9715 |
1.B.6.2.10 | Outer membrane porin, OmpX of 171 aas (Dupont et al. 2004). | Bacteria |
Pseudomonadota | OmpX of Enterobacter (Aerobacter) aerogenes |
1.B.6.2.11 | Outer membrane porin, opacity type, of 189 aas | Bacteria |
Chlorobiota | OMP of Prosthecochloris vibrioformis |
1.B.6.2.12 | Outer membrane porin, opacity type, of 230 aas | Bacteria |
Chlorobiota | OMP of Chlorobaculum parvum |
1.B.6.2.13 | Putative invasin of 242 aas | Bacteria |
Pseudomonadota | Putative invasin of E. coli |
1.B.6.2.14 | Uncharacterized protein of 290 aas | Bacteria |
Pseudomonadota | UP of Nitrobacter hamburgensis |
1.B.6.2.15 | Putative porin of 199 aas | Bacteria |
Pseudomonadota | Putative porin of Rhodanobacter thiooxydans |
1.B.6.2.16 | Uncharacterized protein of 196 aas | Bacteria |
Pseudomonadota | UP of Vibrio fischeri |
1.B.6.2.17 | Putative porin of 195 aas | Bacteria |
Pseudomonadota | Putative porin of Vibrio alginolyticus |
1.B.6.2.18 | Uncharacterized protein of 186 aas | Bacteria |
Pseudomonadota | UP of Agarivorans albus |
1.B.6.2.19 | Putative porin of 182 aas | Bacteria |
Pseudomonadota | PP of Grimontia hollisae |
1.B.6.2.20 | Ail/Lom protein of 199 aas | Bacteria |
Pseudomonadota | Ail/Lom protein of E. coli |
1.B.6.3.1 | Putative porin of 197 aas | Bacteria |
Verrucomicrobiota | PP of Opitutaceae bacterium TAV1 |
1.B.6.3.2 | Putative porin of 277 aas | Bacteria |
Verrucomicrobiota | PP of Coraliomargarita sp. CAG:312 |
1.B.6.3.3 | Putative porin | Bacteria |
Verrucomicrobiota | PP of Opitutus terrae |
1.B.6.4.1 | Putative porin of 183 aas | Bacteria |
Pseudomonadota | Putative porin of Vibrio parahaemolyticus |
1.B.6.4.2 | Porin of 190 aas and 1 N-terminal TMS. | Bacteria |
Pseudomonadota | Porin of Shewanella psychrophila |
1.B.6.4.3 | Porin of 198 aas and 1 N-terminal TMS. | Bacteria |
Pseudomonadota | Porin of Pseudoalteromonas luteoviolacea |
1.B.6.4.4 | Porin of 180 aas and 1 N-terminal TMS | Bacteria |
Pseudomonadota | Porin of Vibrio caribbeanicus |
1.B.6.4.5 | Porin of 186 aas and 1 N-terminal TMS | Bacteria |
Pseudomonadota | Porin of Litorilituus sp. RZ04 |
1.B.6.5.1 | Outer membrane protein of 205 aas and 8 putative TMSs. | Bacteria |
Fibrobacterota | OMP of Fibrobacter succinogens |
1.B.6.5.2 | Outer membrane protein of 197 aas and 8 putative TMSs. | Bacteria |
Fibrobacterota | OMP of Fibrobacter succinogenes |
1.B.6.5.3 | Outer membrane protein of 534 aas and 6 - 22 beta strands. | Bacteria |
Spirochaetota | OMP of Turneriella parva |
1.B.6.5.4 | Outer membrane protein of 211 aas and 8 beta strands. | Bacteria |
Myxococcota | OMP of Myxococcus xanthus |
1.B.6.5.5 | Outer membrane protein of 201 aas and 9 putative beta strands. | Bacteria |
Pseudomonadota | OMP of Vibrio tubiashii |
1.B.6.5.6 | Outer membrane protein, OmpA of 196 aas and 8 putative TMSs | Bacteria |
Pseudomonadota | OmpA of Aliivibrio salmonicida |
1.B.6.6.1 | Outer membrane protein of 201 aas and 8 putative β-TMSs. | Bacteria |
Bacteroidota | OMP of Cyclobacterium marinum |
1.B.6.6.2 | Outer membrane protein of 224 aas and 8 TMSs | Bacteria |
Bacteroidota | OMP of Dyadobacter fermentans |
1.B.6.6.3 | Outer membrane protein of 204 aas and 8 TMSs | Bacteria |
Bacteroidota | OMP of Solitalea canadensis |
1.B.6.6.4 | Outer membrane protein of 221 aas and 8 TMSs | Bacteria |
Bacteroidota | OMP of Psychroflexus torquis |
1.B.6.6.5 | Outer membrane protein of 222 aas | Bacteria |
Bacteroidota | OMP of Echinicola vietnamensis |
1.B.6.6.6 | Outer membrane protein of 199 aas | Bacteria |
Bacteroidota | OMP of Chitinophaga pinensis |
1.B.6.6.7 | Porin of 193 aas and 8 beta strands | Bacteria |
Bacteroidota | Porin of Flavobacterium johnsoniae |
1.B.6.6.8 | Porin of 180 aas and 8 beta strands | Bacteria |
Nitrospirota | Porin of Candidatus Nitrospira defluvii |
1.B.6.6.9 | Porin of 207 aas and 8 beta strands | Bacteria |
Myxococcota | Porin of Myxococcus xanthus |
1.B.6.6.10 | Putative porin of 157 aas and 8 beta strands | Bacteria |
Bacteroidota | Putative porin of Paludibacter propionicigenes |
1.B.6.6.11 | Uncharacterized protein of 208 aas. | Bacteria |
Bacteroidota | UP of Pedobacter saltans |
1.B.6.6.12 | Putative porin of 192 aas | Bacteria |
Bacteroidota | Putative porin of Capnocytophaga sputigena |
1.B.6.7.1 | Outer membrane protein of 257 aas and 8 beta strands | Bacteria |
Bacteroidota | OMP of Bacteroides fragilis |
1.B.6.7.2 | Porin of 275 aas and 1 N-terminal TMS | Bacteria |
Bacteroidota | Porin of Bacteroides xylanisolvens |
1.B.6.7.3 | DUF4421 domain-containing protein of 334 aas and 1 N-terminal TM | Bacteria |
Bacteroidota | Putative porin of Flavobacterium rivuli |
1.B.6.8.1 | Porin of 224 aas and 8 beta strands, TtoA (Estrada Mallarino et al. 2015). The crystal structure is known (3DZM) (Nesper et al. 2008). The 2.8 Å structure reveals a transmembrane 8 stranded β-barrel, an extracellular cation-binding region and an external 5-β stranded sheet (Brosig et al. 2009). | Bacteria |
Deinococcota | Porin of Thermus thermophilus |
1.B.6.8.2 | Putative porin of 222 aas. | Bacteria |
Deinococcota | Putative porin of Deinococcus geothermalis |
1.B.6.8.3 | Putative porin of 227 aas and 1 N-terminal TMS | Bacteria |
Ignavibacteriota | Porin of Ignavibacterium album |
1.B.6.9.1 | Uncharacterized protein of 186 aas. | Bacteria |
Ignavibacteriota | UP of Ignavibacterium album |
1.B.6.9.2 | Uncharacterized putative porin protein of 189 aas. | Bacteria |
Bacteroidota | UP of Owenweeksia hongkongensis |
1.B.6.9.3 | Uncharacterized putative porin of 205 aas | Bacteria |
Bacteroidota | Putative porin of Owenweeksia hongkongensis |
1.B.6.9.4 | Uncharacterized protein of 167 aas | Bacteria |
Bacteroidota | UP of Elizabethkingia anophelis |
1.B.6.10.1 | Putative OmpW homologue of 219 aas (Giacani et al. 2015). | Bacteria |
Spirochaetota | Putative OmpW homologue of Treponema pallidum |
1.B.6.10.2 | Putative OmpW homologue of 291 aas (Giacani et al. 2015). | Bacteria |
Spirochaetota | Putative OmpW homologue of Treponema pallidum |
1.B.6.10.3 | Putative OmpW porin of 211 aas and 8 β-strands | Bacteria |
Spirochaetota | Putative OmpW homologue of Treponema azotonutricium |
1.B.6.10.4 | Putative OmpW homologue of 206 aas and 8 β-strands. | Bacteria |
Spirochaetota | Putative OmpW homologue of Spirochaeta africana |
1.B.6.10.5 | Putative OmpW homologue of 211 aas | Bacteria |
Spirochaetota | OmpW homologue of Borrelia hermsii |
1.B.6.10.6 | Uncharacterized protein of 196 aas. | Bacteria |
Spirochaetota | UP of Sphaerochaeta pleomorpha |
1.B.6.10.7 | Uncharacterized protein of 205 aas. | Bacteria |
Spirochaetota | UP of Treponema denticola |
1.B.6.11.1 | Putative porin of 357 aas and 1 N-terminal TMS | Archaea |
Euryarchaeota | Porin of Candidatus Methanoperedenaceae archaeon |
1.B.6.11.2 | Uncharacterized protein of 407 aas | Ciliophora | UP of Stentor coeruleus | |
1.B.6.12.1 | A major outer membrane protein of 298 aas and 1 N-terminal TMS, from Methylacidiphilum fumariolicum SolV (Liu et al. 2023). This porin has a β-barrel structure consisting of ten antiparallel β-sheets and with a small amphipathic N-terminal α-helix in the periplasm. Because M. fumariolicum SolV, lives in a geothermal environment with low pH and high temperatures, this protein may act as barrier to resist the extreme conditions found in its natural environment (Liu et al. 2023). | Bacteria |
Verrucomicrobiota | Major OM Porin, WP_009059494, of Methylacidiphilum fumariolicum SolV |
1.B.6.12.2 | Uncharacterized opacity protein or related surface antigen of 278 aas and 1 N-terminal TMS. This protein is also distantly related to members of TC family 1.B.49. | Bacteria |
Planctomycetota | UP of a Bradyrhizobium sp. S23321 [Gemmataceae bacterium] |
1.B.6.12.3 | Outer membrane beta-barrel protein of 306 aas and 1 N-terminal TMS. This protein resembles members of TC family 1.B.49. a member of theOMPP1 Superfamily. | Bacteria |
Verrucomicrobiota | OMP of Candidatus Methylacidithermus pantelleriae |
1.B.6.13.1 | Putative lipoprotein, YiaD, of 219 aas with 3 N-terminal TMSs and a C-terminla OmpA peptidoglycan binding domain. When expressed in a multicopy plasmid, its expression supressed the phenotype of a bamD ts mutant (Tachikawa and Kato 2011). | Bacteria |
Pseudomonadota | YiaD of E. coli |
1.B.6.13.2 | Uncharacterized protein of 212 aas and 3 N-terminal TMSs plus a C-terminal OmpA peptidoglycan binding domain. | Bacteria |
Fusobacteriota | UP of Fusobacterium periodonticum |
1.B.6.13.3 | Uncharacterized protein of 226 aas with 3 N-terminal TMSs and a C-terminal OmpA domain. | Bacteria |
Bacteroidota | UP of Prevotella ruminicola |
1.B.6.13.4 | Putative uncharacterized porin of 368 aas | Bacteria |
Bdellovibrionota | UP of Bdellovibrio bacteriovorus |
1.B.6.13.5 | ArfA, a member of the OmpA family. It is of 471 aas with 3 N-terminal TMSs. It affects cell stiffness, cell shape and virulence (Scribano et al. 2024). | Bacteria |
Pseudomonadota | ArfA of Acinetobacter baumannii |