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1.B.8.1.2
VDAC3 porin.  The human orthologue forms small pores in membranes (Checchetto et al. 2014).  VDAC3 is a sensor of the oxidative state in the mitochondrial intermembrane space, and cysteyl residue modification appears to play a role (Reina et al. 2016). Post translational modifications of VDAC3 that can impact its protective role against reactive oxygen species (ROS), which is particularly important in the ALS context (Pittalà et al. 2022).  The VDAC3/DHODH axis ameliorates sepsis-induced myocardial injury by regulating ferroptosis (Wang et al. 2025).

Accession Number:Q60931
Protein Name:POR3 aka VDAC3
Length:283
Molecular Weight:30753.00
Species:Mus musculus (Mouse) [10090]
Location1 / Topology2 / Orientation3: Mitochondrion outer membrane1
Substrate molecule

Cross database links:

RefSeq: NP_035826.1   
Entrez Gene ID: 22335   
Pfam: PF01459   
KEGG: mmu:22335   

Gene Ontology

GO:0005743 C:mitochondrial inner membrane
GO:0005741 C:mitochondrial outer membrane
GO:0046930 C:pore complex
GO:0000166 F:nucleotide binding
GO:0008308 F:voltage-gated anion channel activity
GO:0006820 P:anion transport
GO:0001662 P:behavioral fear response
GO:0007612 P:learning
GO:0007270 P:nerve-nerve synaptic transmission
GO:0055085 P:transmembrane transport

References (5)

[1] “A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8.”  Sampson M.J.et.al.   8812436
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.”  Kim S.C.et.al.   16916647
[5] “Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.”  Ballif B.A.et.al.   18034455

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FASTA formatted sequence 
1:	MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVE FSTSGHAYTD TGKASGNLET 
61:	KYKVCNYGLT FTQKWNTDNT LGTEISWENK LAEGLKLTLD TIFVPNTGKK SGKLKASYRR 
121:	DCFSLGSNVD IDFSGPTIYG WAVLAFEGWL AGYQMSFDTA KSKLSQNNFA LGYKAADFQL 
181:	HTHVNDGTEF GGSIYQKVNE RIETSINLAW TAGSNNTRFG IAAKYKLDCR TSLSAKVNNA 
241:	SLIGLGYTQT LRPGVKLTLS ALIDGKNFNA GGHKVGLGFE LEA