1.B.8.1.20
Miltochondrial outer membrane porin, VDAC, of 283 aas. The channel adopts an open conformation at low or
zero membrane potential and a closed conformation at potentials above
30-40 mV. The open state has a weak anion selectivity whereas the closed
state is cation-selective. The absence of VDAC is associated with increased reactive oxygen species (ROS) production (Shuvo et al. 2019).
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| Accession Number: | P07144 |
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| Protein Name: | Mitochondrial outer membrane protein porin |
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| Length: | 283 |
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| Molecular Weight: | 30000.00 |
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| Species: | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [367110] |
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| Location1 / Topology2 / Orientation3: |
Mitochondrion outer membrane1 |
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| Substrate |
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1: MAVPAFSDIA KSANDLLNKD FYHLAAGTIE VKSNTPNNVA FKVTGKSTHD KVTSGALEGK
61: FTDKPNGLTV TQTWNTANAL ETKVEMADNL AKGLKAEGIF SFLPATNARG AKFNLHFKQS
121: NFHGRAFFDL LKGPTANIDA IVGHEGFLAG ASAGYDVQKA AITGYSAAVG YHAPTYSAAI
181: TATDNLSVFS ASYYHKVNSQ VEAGSKATWN SKTGNTVGLE VATKYRIDPV SFVKGKINDR
241: GVAAIAYNVL LREGVTLGVG ASFDTQKLDQ ATHKVGTSFT FES