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1.B.8.1.6
Voltage-dependent anion-selective porin1 (Porin-1, VDAC or Por-1) (De Pinto et al. 1989; Aiello et al., 2004) (one of three paralogues). Mutations in VDAC leads to neurologic dysfunction and male infertility in Drosophila  (Graham et al., 2010).  Porin 1 is abundantly expressed in both male and female germ cell tissues; Porin 2 is abundant in testis but in small amounts in ovaries. The immuno-histological stain of ovaries shows that Porin isoform 1 is selectively targeted to follicular cells while Porin isoform 2 is present in mitochondria of the epithelial sheath cells of the ovariole (Guarino et al. 2006; Specchia et al. 2008).

Accession Number:Q94920
Protein Name:Voltage-dependent anion-selective channel aka porin1
Length:282
Molecular Weight:30550.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Location1 / Topology2 / Orientation3: Mitochondrion outer membrane1
Substrate anion

Cross database links:

DIP: DIP-17501N
RefSeq: NP_001033899.1    NP_476813.1    NP_599110.1   
Entrez Gene ID: 34500   
Pfam: PF01459   
BioCyc: DMEL-XXX-02:DMEL-XXX-02-008473-MONOMER    DMEL-XXX-02:DMEL-XXX-02-008474-MONOMER   
KEGG: dme:Dmel_CG6647   

Gene Ontology

GO:0005811 C:lipid particle
GO:0005741 C:mitochondrial outer membrane
GO:0016006 C:Nebenkern
GO:0046930 C:pore complex
GO:0008308 F:voltage-gated anion channel activity
GO:0006820 P:anion transport
GO:0007602 P:phototransduction
GO:0055085 P:transmembrane transport

References (7)

[1] “Cloning and molecular characterization of a voltage-dependent anion-selective channel (VDAC) from Drosophila melanogaster.”  Ryerse J.S.et.al.   9271262
[2] “Cloning and chromosomal localization of a cDNA encoding a mitochondrial porin from Drosophila melanogaster.”  Messina A.et.al.   8797793
[3] “Sequence and expression pattern of the Drosophila melanogaster mitochondrial porin gene: evidence of a conserved protein domain between fly and mouse.”  Oliva M.et.al.   9688565
[4] “Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database.”  Caggese C.et.al.   10071211
[5] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[6] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[7] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MAPPSYSDLG KQARDIFSKG YNFGLWKLDL KTKTSSGIEF NTAGHSNQES GKVFGSLETK 
61:	YKVKDYGLTL TEKWNTDNTL FTEVAVQDQL LEGLKLSLEG NFAPQSGNKN GKFKVAYGHE 
121:	NVKADSDVNI DLKGPLINAS AVLGYQGWLA GYQTAFDTQQ SKLTTNNFAL GYTTKDFVLH 
181:	TAVNDGQEFS GSIFQRTSDK LDVGVQLSWA SGTSNTKFAI GAKYQLDDDA SVRAKVNNAS 
241:	QVGLGYQQKL RDGVTLTLST LVDGKNFNAG GHKIGVGLEL EA