1.C.11.1.8
Leukotoxin, RtxA or IktA, of 956 aas and 3 or 4 TMSs in a 1 + 1 + 2 TMS arrangement. An interaction between the toxin and cholesterol occurs via two
cholesterol recognition/interaction amino acid consensus motifs located
in the C-terminal portion of the pore-forming domain of the toxin, and the cytotoxic activity of RtxA
depends on post-translational acylation of the K558 and/or K689 residues
as well as on the toxin binding to cholesterol in the membrane (Osickova et al. 2018).
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| Accession Number: | A1YKW7 |
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| Protein Name: | Leukotoxin |
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| Length: | 956 |
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| Molecular Weight: | 101210.00 |
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| Species: | Kingella kingae [504] |
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| Number of TMSs: | 1 |
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| Substrate |
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1: MNLATTKAKL KSGAQAGVQA LNKAGHAAKT GTVAAGKATV AGAKSLYLTI PKDYDIEKGG
61: SLNELIKAAD ELGIARLQED ANNIESAKKS IDTVEKLLSF TQTGVAVSAK KLDELLQKYS
121: SSQLAKSLGS SANIDSKLTK TNHILSTLSS FLGTALAGMD LDSLVKQGDA SATDLAKASL
181: DLINELVNNI SNSVQSIEAF SEQLGRLGAA ISQTKGLSGL GNKLQNLPNF GKANLALEMI
241: SGLLSGISAG FTLADKNAST EKKVAAGFEL SNQVIGNVTK AISSYVLAQR AAAGLSTTGA
301: VASLITASIM LAISPLAFMN AADKFKNASL IDEFAKQFKK FGYDGDSLLA EYQRGAGTIE
361: ASLTAINTAL GAVSAGVSAA AVGSVVGSPV ALLVAGVTGL ISGILEASKQ AMFESVANRL
421: QSKILAWEKE NGGKNYFENG YDARHAHYLE RNLKLLSELN KELQAERVIA ITQQRWDANI
481: GELAGITKLG DRISSGKAYA DAFEDGKKLD GASNVTVDTR TGVVDISNAN GKKTQALHFT
541: SPLLTAGTET RERVQNGKYS YINQLKFNRV KSWTVKDGEA NSRLDFSKVI QHVAFNDEDG
601: RLSGKTEEIA LNVNAGSGND DIFAGQGKMN VDGGTGHDRV FYSKDGGLGQ VNVDGTKATE
661: AGSYTVNRSI NNGSFYHEVI KRQTTQVGKR TETLEYRDFE LKRPEHGYQT TDTLKSVEEI
721: VGSQFSDTFK GSKFADIFHG GDGNDTLEGN DGDDRLFGGN GDDHLYGGNG DDLLDGGKGN
781: DVINGGDGND VYISRKGDGN DTLYDSHGSD KLAFADADLS ELTIERTAQG IMIKRNDGSG
841: SINMAEWYKT LSQQNYHGNA TDDKIEQIIG KNGDYITSEQ IDKLLKDKQT GTITSAQLQQ
901: LAQENKSKSI DSGNLASTLN KLIESMASFG SRGATASNYL QPAHKSPQNV LAPSAV