1.C.112.1.1
Cubozoan toxin, CaTX-A of 463 aas. This toxin has
potent hemolytic activity, is lethal to crayfish. causes cutaneous
inflammation in humans, and may act as a pore-forming toxin, disrupting
normal transmembrane ion concentration gradients in susceptible cells (Nagai et al. 2000; Brinkman and Burnell 2009).
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| Accession Number: | Q9GNN8 |
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| Protein Name: | Toxin CaTX-A |
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| Length: | 463 |
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| Molecular Weight: | 51605.00 |
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| Species: | Carybdea alata (Hawaiian box jellyfish) [112899] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
ion |
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1: MSRGYSLHLV LFLVLSTAFP SQARLSRYRR SAADAVSTDI DGIIGQLNDL GTDTKRLKEA
61: LQGVQEAVKK EPATTIAKVS TIVGSVGGSL SKFKSGDPFD VASGCLDIIA SVATTFGGPY
121: GIAIGAVASL ISSILSLFSG NSMGSAIKQV IDDAFKKYRD QELEDNVKGA KRTFNAVITF
181: VNSVSKTENL TEVHLDSVRD AVRVDAFTNM LGVLESRINR GSVSTDNNEA MRTINFIFLY
241: LQLSVMRETL LTQVILLYKR AGGAYDELAL SLSLTSDQNK EATRETVTFL HQMETKYSLC
301: GSYYYPIDHS KAAIGILKLT KFFGVPDPAR YTFDGLYYRM QNRAWNRYSI CKESYAGNHM
361: FRGCKDSSYH GIRIKKLENG YHTITLRSKA MYVTKHAQGW GWGTADEDPG EQGYFTFIPL
421: TNGFYMVSTK KWPDYFVYME SSAHGYIRSW HYNPDPQGQW KIL