1.C.112.1.9
CrTx-A cytotoxin of 450 aas with 4 probable TMSs, one at the N-terminus, two at about residue110, and a fourth at about residue 230. It has potent hemolytic activity and is lethal to mice and crayfish (Nagai et al. 2000). It causes cutaneous inflammation in humans and may act as a pore-forming toxin, disrupting normal transmembrane ion concentration gradients in susceptible cells.
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| Accession Number: | Q9GV72 |
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| Protein Name: | Toxin CrTX-A |
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| Length: | 450 |
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| Molecular Weight: | 49392.00 |
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| Species: | Carybdea rastonii (Box jellyfish) [78582] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MILKHLPWLF IVLAITSAKH GKRSDVNSLL TKVETALKEA SGSNEAALEA LEGLKGEIQT
61: KPDRVGQATK ILGSVGSALG KLNSGDATKI ISGCLDIVAG IATTFGGPVG MGIGAVASFV
121: SSILSLFTGS SAKNSVAAVI DRALSKHRDE AIQRHAAGAK RDFAESSAFI QVMKQQSNLT
181: DSDLSIIAAN VPVYKFSNFI GQLESRISQG AATTSLSDAK RAVDFILLYC QLVVMRETLL
241: VDLAILYRKG NAEHVASAVE NANRVNKELA ADTLDFLHKL IPEQALIGAV YHPISASETS
301: KAILNYTKYF GVPDVPRPIG NRRYKFTNSY WNTYSICSEA YMGNYMFRGC SNVRNPNIRV
361: SKMSDGFYTM ENSDRRKLYI TKHDQGWGWG TLDEDPGDQG HMRFIPLRHG KYMVSSKRWP
421: NWFMYMESSA SGYIRSWENN PGPQGHWSIT