Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.C.12.1.4
Streptolysin O, SLO or SpyM3, (transports NAD-glycohydrolase into the host cell) (Meehl and Caparon, 2004).  Injections into cells modulates cell metabolism which induces streptolysin synthesis and S. pyogenes growth (Baruch et al. 2014). This sulfhydryl-activated toxin causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion. The domino-like prepore-to-pore transition of Streptolysin O has been visualized (Ariyama 2022).  

Accession Number:P0C0I3
Protein Name:Streptolysin O aka TACY aka SLO
Length:571
Molecular Weight:63638.00
Species:Streptococcus pyogenes serotype M1/M3 [301447]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate

Cross database links:

RefSeq: NP_268546.1    YP_281505.1   
Entrez Gene ID: 3572764    900490   
Pfam: PF01289   
BioCyc: SPYO160490:SPY0167-MONOMER    SPYO293653:M5005_SPY0141-MONOMER   
KEGG: spy:SPy_0167    spz:M5005_Spy_0   

Gene Ontology

GO:0005576 C:extracellular region
GO:0015485 F:cholesterol binding
GO:0019835 P:cytolysis
GO:0019836 P:hemolysis by symbiont of host erythrocytes
GO:0009405 P:pathogenesis

References (2)

[1] “Complete genome sequence of an M1 strain of Streptococcus pyogenes.”  Ferretti J.J.et.al.   11296296
[2] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.”  Sumby P.et.al.   16088826

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MSNKKTFKKY SRVAGLLTAA LIIGNLVTAN AESNKQNTAS TETTTTNEQP KPESSELTTE 
61:	KAGQKTDDML NSNDMIKLAP KEMPLESAEK EEKKSEDKKK SEEDHTEEIN DKIYSLNYNE 
121:	LEVLAKNGET IENFVPKEGV KKADKFIVIE RKKKNINTTP VDISIIDSVT DRTYPAALQL 
181:	ANKGFTENKP DAVVTKRNPQ KIHIDLPGMG DKATVEVNDP TYANVSTAID NLVNQWHDNY 
241:	SGGNTLPART QYTESMVYSK SQIEAALNVN SKILDGTLGI DFKSISKGEK KVMIAAYKQI 
301:	FYTVSANLPN NPADVFDKSV TFKELQRKGV SNEAPPLFVS NVAYGRTVFV KLETSSKSND 
361:	VEAAFSAALK GTDVKTNGKY SDILENSSFT AVVLGGDAAE HNKVVTKDFD VIRNVIKDNA 
421:	TFSRKNPAYP ISYTSVFLKN NKIAGVNNRT EYVETTSTEY TSGKINLSHQ GAYVAQYEIL 
481:	WDEINYDDKG KEVITKRRWD NNWYSKTSPF STVIPLGANS RNIRIMAREC TGLAWEWWRK 
541:	VIDERDVKLS KEINVNISGS TLSPYGSITY K