1.C.12.1.9
The cholesterol-dependent pore-forming cytoslysin, Pyolysin of 534 aas with one N-terminal TMS. The pathology of Trueperella pyogenes and this pyolysin have been described and reviewed (Rzewuska et al. 2019). Liu et al. 2022 located and mutated two different highly conserved structural sites in the primary sequence of the protein that are critical for PLO structure and function.
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| Accession Number: | O31241 |
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| Protein Name: | PLO |
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| Length: | 534 |
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| Molecular Weight: | 57873.00 |
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| Species: | Arcanobacterium pyogenes [1661] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
molecule |
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| Pfam: |
PF01289
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[1] “The Arcanobacterium (Actinomyces) pyogenes hemolysin, pyolysin, is a novel member of the thiol-activated cytolysin family.” Billington S.J. et.al. 9324258
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1: MKRKAFASLV ASVVAAATVT MPTASFAAGL GNSSGLTDGL SAPRASISPT DKVDLKSAQE
61: TDETGVDKYI RGLKYDPSGV LAVKGESIEN VPVTKDQLKD GTYTVFKHER KSFNNLRSDI
121: SAFDANNAHV YPGALVLANK DLAKGSPTSI GIARAPQTVS VDLPGLVDGK NKVVINNPTK
181: SSVTQGLNGL LDGWIQRNSK YPDHAAKISY DETMVTSKRQ LEAKLGLGFE KVSAKLNVDF
241: DAIHKRERQV AIASFKQIYY TASVDTPTSP HSVFGPNVTA QDLKDRGVNN KNPLGYISSV
301: SYGRQIFVKL ETTSTSNDVQ AAFSGLFKAK FGNLSTEFKA KYADILNKTR ATVYAVGGSA
361: RGGVEVATGN IDALKKIIKE ESTYSTKVPA VPVSYAVNFL KDNQLAAVRS SGDYIETTAT
421: TYKSGEITFR HGGGYVAKFR LKWDEISYDP QGKEIRTPKT WSGNWAARTL GFRETIQLPA
481: NARNIHVEAG EATGLAWDPW WTVINKKNLP LVPHREIVLK GTTLNPWVED NVKS