1.C.137.1.1
Gasdermin bGSDM of 259 aas and 1 possible TMS at residue 85. It is the precursor of a pore-forming protein involved in defense
against bacteriophages. Expression of gasdermin bGSDM and the neighboring protease
gene (Ga0098714_109514) is toxic in E.coli on solid medium (Johnson et al. 2022). Cleavage
of this precursor by its dedicated protease releases the active moiety
(gasdermin bGSDM, N-terminus), which inserts into membranes, forming
pores and triggering cell death.
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| Accession Number: | P0DV46 |
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| Protein Name: | Gasdermin bGSDM |
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| Length: | 259 |
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| Molecular Weight: | 27597.00 |
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| Species: | Bradyrhizobium tropiciagri [312253] |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MNCSRDTGDE LMAALLAEGI NLILPPRDNI APGDLIIADP QGGARLGGWH EVFNLQLSPE
61: VATDPGFKSF QFRASSILQV GVAASVMGRV LQALGLGSGS FSSAFSSSNA DTIQLSIVAP
121: ANKELTNFDA VLVQMNEAKA EPAQGYTDRN FFVVTKVWRA RGIRISVADK SKKQVDLSAK
181: AVEELTAKAK MELKREDTGS YAFLAASQLI FGLTLREVTY KDGAIVDVAP TGPLKFRGKG
241: PGDPFAFIGD DAFVDLPES