1.C.16.1.1
Magainin precursor of 333 aas and 1 TMS.  3-d structural determinations and simulations show the oligomeric states, transmembrane helices and tilt angles in the various states of the mature Maganin (Pino-Angeles et al. 2016).  Forms stable heterooligomers with PglA (TC# 1.C.16.1.5) at lower concentrations of the two peptides than allows each one alone to form pores in which PglA, rather than magainin 2 forms the pore (Strandberg et al. 2016). Mixtures of peptides such as magainin 2 and PGLa, which are stored and secreted naturally as a cocktail, exhibit considerably enhanced antimicrobial activities when investigated together in antimicrobial assays and also in pore forming experiments applied to biophysical model systems. Investigations have revealed that these peptides do not form stable complexes but act by specific lipid-mediated interactions and are influenced by the nanoscale properties of phospholipid bilayers (Juhl et al. 2021).