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1.C.18.1.1
Melittin major precursor (anion selective).  Its bacteriocidal activity against Listeria and its cytotoxicity to animal cells have been studied (Wu et al. 2016). In zwitterionic membranes, melittin forms transmembrane toroidal homomeric pores supported by four to eight peptides. Its ability to diffuse freely in a 1,2-dimyristoyl-SN-glycero-3-phosphocholine membrane leads to dynamic pores of vaious diameters with varying molecularity containing from 4 to peptides/channel (Pino-Angeles and Lazaridis 2018).

Accession Number:P01501
Protein Name:MEL aka MELT
Length:70
Molecular Weight:7585.00
Species:Apis mellifera (Honeybee), and Apis cerana (Indian honeybee) [7460]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Secreted1
Substrate molecule, water, polyelectrolyte macromolecule

Cross database links:

RefSeq: NP_001011607.1   
Entrez Gene ID: 406130   
Pfam: PF01372   
KEGG: ame:406130   

Gene Ontology

GO:0005576 C:extracellular region
GO:0046930 C:pore complex
GO:0004860 F:protein kinase inhibitor activity
GO:0019835 P:cytolysis
GO:0019836 P:hemolysis by symbiont of host erythrocytes
GO:0006811 P:ion transport
GO:0009405 P:pathogenesis

References (7)

[1] “Nucleotide sequence of cloned cDNA coding for honeybee prepromelittin.”  Vlasak R.et.al.   6309516
[2] “Sequence analysis of melittin from tryptic and peptic degradation products.”  Habermann E.et.al.   5592400
[3] “Haemolytic activity and action on the surface tension of aqueous solutions of synthetic melittins and their derivatives.”  Schroeder E.et.al.   5139482
[4] “Isolation and structure of N 1-formyl melittin.”  Luebke K.et.al.   5139483
[5] “Isolation and structures of grammistins, peptide toxins from the skin secretion of the soapfish Grammistes sexlineatus.”  Shiomi K.et.al.   10669014
[6] “The structure of melittin. II. Interpretation of the structure.”  Terwilliger T.C.et.al.   7076662
[7] “The actions of melittin on membranes.”  Dempsey C.E.et.al.   2187536
Structure:
1BH1   2MLT   2MW6   3QRX   6DST   6O4M     

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MKFLVNVALV FMVVYISYIY AAPEPEPAPE PEAEADAEAD PEAGIGAVLK VLTTGLPALI 
61:	SWIKRKRQQG