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1.C.2.1.4
Cry1Ac (85% identical to Cry1Aa (TC#1.C.2.1.1). May use MRP-4-like ABC transporter as a receptor in Bombyx mori (Atsumi et al., 2012). An miR-310 mediated response to Cry1Ac protoxin in Plutella xylostella (L.) has been documented (Yang et al. 2022).  The insecticidal crystalline (Cry) and vegetative insecticidal (Vip) proteins derived from Bacillus thuringiensis (Bt) are used globally to manage insect pests, including the cotton bollworm, Helicoverpa armigera, one of the world's most damaging agricultural pests. Cry proteins bind to the ATP-binding cassette transporter C2 (ABCC2) receptor on the membrane surface of larval midgut cells, resulting in Cry toxin pores, and ultimately leading to cell swelling and/or lysis. Insect aquaporin (AQP) proteins within the membranes of larval midgut cells allow the rapid influx of water into enterocytes following the osmotic imbalance triggered by the formation of Cry toxin pores (Cai et al. 2024).

Accession Number:D3XF72
Protein Name:Cry1Ac
Length:1171
Molecular Weight:132340.00
Species:Bacillus thuringiensis [1428]
Substrate molecule

Cross database links:

Pfam: PF03944    PF00555    PF03945   

Gene Ontology

GO:0006952 P:defense response
GO:0009405 P:pathogenesis
GO:0030435 P:sporulation resulting in formation of a cellular spore

References (1)

[1] “Evidence of the involvement of E358, A498 and C571 of a new Cry1Ac delta-endotoxin of Bacillus thuringiensis in its high insecticidal activity against Ephestia kuehniella.”  Saadaoui I.et.al.   20084474

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MDNNPNINEC IPYNCLSNPE VEVLGGERIE TGYTPIDISL SLTQFLLSEF VPGAGFVLGL 
61:	VDIIWGIFGP SQWDAFLVQI EQLINQRIEE FARNQAISRL EGLSNLYQIY AESFREWEAD 
121:	PTNPALREEM RIQFNDMNSA LTTAIPLLAV QNYQVPLLSV YVQAANLHLS VLRDVSVFGQ 
181:	RWGFDAATIN SRYNDLTRLI GNYTDYAVRW YNTGLERVWG PDSRDWVRYN QFRRELTLTV 
241:	LDIVALFPNY DSRRYPIRTV SQLTREIYTN PVLENFDGSF RGSAQGIERS IRSPHLMDIL 
301:	NSITIYTDAH RGYYYWSGHQ IMASPVGFSG PEFTFPLYGT MGNAAPQQRI VAQLGQGEYR 
361:	TLSSTFYRRP FNIGINNQQL SVLDGTEFAY GTSSNLPSAV YRKSGTVDSL DEIPPQNNNV 
421:	PPRQGFSHRL SHVSMFRSGS SSSVSIIRAP MFSWIHRSAE FNNIIASDSI TQIPAVKGNF 
481:	LFNGSVISGP GFTGGDLARL NSSGNNIQNR GYIEVPIHFP STSTRYRVRV RYASVTPIHL 
541:	NVNWGNSSIF SNTVPATATS LDNLQSSDFG CFESANAFTS SLGNIVGVRN FSGTAGVIID 
601:	RFEFIPVTAT LEAEYNLERA QKAVNALFTS TNQLGLKTNV TDYHIDQVSN LVTYLSDEFC 
661:	LDEKRELSEK VKHAKRLSDE RNLLQDSNFK DINRQPERGW GGSTGITIQG GDDVFKENYV 
721:	TLSGTFDECY PTYLYQKIDE SKLKAFTRYQ LRGYIEDSQD LEIYLIRYNA KHETVNVPGT 
781:	GSLWPLSAQS PIGKCGEPNR CAPHLEWNPD LDCSCRDGEK CAHHSHHFSL DIDVGCTDLN 
841:	EDLGVWVIFK IKTQDGHARL GNLEFLEEKP LVGEALARVK RAEKKWRDKR EKLEWETNIV 
901:	YKEAKESVDA LFVNSQYDQL QADTNIAMIH AADKRVHSIR EAYLPELSVI PGVNAAIFEE 
961:	LEGRIFAAFS LYDARNVIKN GDFNNGLSCW NVKGHVDVEE QNNQRSVLVV PEWEAEVSQE 
1021:	VRVCPGRGYI LRVTAYKEGY GEGCVTIHEI ENNTDELKFS NCVEEEIYPN NTVTCNDYTV 
1081:	NQEEYGGAYT SRNRGYNEAP SVPADYASVY EEKSYTDGRR ENPCEFNRGY RDYTPLPVGY 
1141:	VTKELEYFPE TDKVWIEIGE TEGTFIVDSV E