1.C.20.1.2
Class I lantibiotic bacteriocin Gallidermin precursor (has a mersacidin-like Lipid II domain, and forms Lipid II-dependent pores) (Sahl and Bierbaum, 1998). The genetic organization, biosynthesis, modification, excretion, extracellular activation of the modified pre-peptide by proteolytic processing, self-protection of the producer, gene regulation, structure, and mode of action have been reviewed (Götz et al. 2014). The Gallidermin-lipid II complex probably forms water pores in the membrane (Pokhrel et al. 2019). It complexes Lipid II more tightly than it forms transmembrane channels (Pokhrel et al. 2021).