1.C.20.1.8
Mutacin 1140 (MU1140) precursor (homologous to several lantibiotics (Smith et al., 2008)).  MU1140-lipid II complexes form water permeating membrane pores (Pokhrel et al. 2019). A single chain of MU1140 complexed with lipid II allows transport across the membrane via a single-file water transport mechanism. The ordering of the water molecules in the single-file chain region as well as the diffusion behavior is similar to those observed in other biological water channels. Multiple complexes of MU1140-lipid II in the membrane showed enhanced permeability for the water molecules, as well as a noticeable membrane distortion and lipid relocation, suggesting that a higher concentration of MU1140 assembly in the membrane can cause significant disruption of the bacterial membrane (Pokhrel et al. 2019). It complexes Lipid II more tightly than it forms transmembrane channels (Pokhrel et al. 2021).