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1.C.35.3.2 Granulosin of 145 aas and 1 TMS. Functions probably by pore-formation by natural killer (NK) and T lympocyces to combat intracellular parasites, both bacterial and eukaryotic (Dotiwala et al. 2016).
Accession Number:	P22749
Protein Name:	GNLY aka NKG5 aka LAG2 aka TLA519
Length:	145
Molecular Weight:	16374.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	1
Location¹ / Topology² / Orientation³:	Secreted¹
Substrate	molecule

Structure:
RefSeq:	NP_006424.2 NP_036615.2
Entrez Gene ID:	10578
Pfam:	PF03489
OMIM:	188855 gene
KEGG:	hsa:10578
Gene Ontology GO:0005615 C:extracellular space GO:0006968 P:cellular defense response GO:0042742 P:defense response to bacterium GO:0050832 P:defense response to fungus GO:0031640 P:killing of cells of another organism
References (8) [1] “The isolation and sequence of a novel gene from a human functional T cell line.” Jongstra J.et.al. 2434598 [2] “A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein.” Yabe T.et.al. 2212946 [3] “Genomic structure of NKG5, a human NK and T cell-specific activation gene.” Houchins J.P.et.al. 8423048 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells.” Krensky A.M.et.al. 10644038 [6] “An antimicrobial activity of cytolytic T cells mediated by granulysin.” Stenger S.et.al. 9756476 [7] “Biosynthesis of granulysin, a novel cytolytic molecule.” Hanson D.A.et.al. 10449094 [8] “Granulysin crystal structure and a structure-derived lytic mechanism.” Anderson D.H.et.al. 12488100
1L9L

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MATWALLLLA AMLLGNPGLV FSRLSPEYYD LARAHLRDEE KSCPCLAQEG PQGDLLTKTQ 
61:	ELGRDYRTCL TIVQKLKKMV DKPTQRSVSN AATRVCRTGR SRWRDVCRNF MRRYQSRVTQ 
121:	GLVAGETAQQ ICEDLRLCIP STGPL

1.C.35.3.2
Granulosin of 145 aas and 1 TMS. Functions probably by pore-formation by natural killer (NK) and T lympocyces to combat intracellular parasites, both bacterial and eukaryotic (Dotiwala et al. 2016).

Cross database links:

Gene Ontology

References (8)

External Searches:

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1.C.35.3.2Granulosin of 145 aas and 1 TMS. Functions probably by pore-formation by natural killer (NK) and T lympocyces to combat intracellular parasites, both bacterial and eukaryotic (Dotiwala et al. 2016).

Cross database links:

Gene Ontology

References (8)

External Searches:

Analyze:

1.C.35.3.2
Granulosin of 145 aas and 1 TMS. Functions probably by pore-formation by natural killer (NK) and T lympocyces to combat intracellular parasites, both bacterial and eukaryotic (Dotiwala et al. 2016).