1.C.38.1.10
Cytolysin RTX-A of 175 aas. Forms cations-selective hydrophilic pores of
around 1 nm and causes cardiac stimulation and hemolysis. Pore formation
is a multi-step process that involves specific recognition of membrane
sphingomyelin (but neither cholesterol nor phosphatidylcholine) and requires oligomerization of the toxin subunits (Frazão et al. 2012).
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| Accession Number: | P58691 |
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| Protein Name: | Cytolysin RTX-A |
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| Length: | 175 |
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| Molecular Weight: | 19275.00 |
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| Species: | Heteractis crispa (Leathery sea anemone) [175771] |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
molecule |
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1: ALAGAIIAGA SLTFQILDKV LAELGQVSRK IAIGIDNESG GSWTAMNAYF RSGTTDVILP
61: EFVPNQKALL YSGRKNRGPD TTGAVGALAY YMSNGNTLGV MFSVPFDYNL YSNWWDVKVY
121: SGKRRADQAM YEDLYYSNPY RGDNGWHQKN LGYGLKMKGI MTSAGEAIME IRISR