1.C.38.1.12
Fragaceatoxin C (FraC), an alpha-barrel pore-forming protein, a cytolytic actinoporin, of 152 aas (Morante et al. 2015; Rojko et al. 2015).  Pore formation goes through a dimer intermediate and then generates the active octamer. Disrupting the key hydrophobic interaction between V60 and F163 (FraC numbering scheme) in the oligomerization interface of FraC, equinatoxin II (EqtII) and sticholysin II (StII) impairs the pore formation activity (Mesa-Galloso et al. 2016).