1.C.40.1.5
NRF5 protein of 551 aas. Plays a role in the uptake of a range of
molecules including phosphatidylserine, lipids and xenobiotic compounds
from the intestine to surrounding tissues (Choy and Thomas 1999). Possesses lipid transfer
activity and mediates transport of lipids from theintestine to the reproductive
tract. Binds phosphatidylserine and plays a role in the efficient clearance of
cell corpses by mediating phosphatidylserine appearance on phagocytic
cells, thus promoting phagocytic engulfment of apoptotic cells (Zhang et al. 2012). Vital
for embryonic development. Gene deletion leads to extension of the life span (Brejning et al. 2014).
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| Accession Number: | Q93796 |
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| Protein Name: | Nose resistant to fluoxetine protein 5 |
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| Length: | 551 |
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| Molecular Weight: | 60851.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
lipid, phosphatidyl-L-serine, xenobiotic |
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1: MSRNFHIFFL LVSIIQVGNS ADSSEITHKP AGIYVRLNQK AVDYVADLAS DALPAILNNL
61: SPPDIVTDMA KITKLHISNV AKPNLSAKFI DGKGVAYNIS LASFRASAYA EISVFVWSYE
121: GDFTAELREL SIESELHFDY NGTTTVNASV CNVTHSELSL VFPPGSSLSA LQSEIKGQIV
181: SALRDAVCTT AVEALTFVMA QKPIPPESPN YQKPEAGDPN GFSVAELGAS LCQVDTVNGF
241: EDSEQEEGNV ETTVAPTPDD DNSTLTTEET QKSYWGVDLS VNHPPTFTDE DMIIGLDGGI
301: LFNGWKADSA QQLQILNKTR LDKKMVGILL SEYIPNTLFH HIYMYDLGNF KHRYTPSSLP
361: KILQKLSKAV CSKCYVEVSA NLTEQPILQI DAHLGARVQL SGNVSIMFHG REQLHDVLHA
421: NTKLHVTLKP TVRHSRIFGD VSLTNVDVNV FDLGLGGPLA APIEKLFSFV VPRVLWPQVK
481: KRLRFAMNRR GVKLPIFCGV ELEHTELDFV DHAVLLNTDF SFDLPLFLAK FKKYLDAKSK
541: INPNLPKYVI I