1.C.46.2.3
Sothern et al. 1995 Natriuretic peptide A of 151 aas, NPPA. The atrial NPPA is a hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (Sothern et al. 1995). It acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (Rubattu et al. 2014).It regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (Sothern et al. 1995).