TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
1.C.48.1.1 | Major prion protein precursor PrP (yielding peptide PrP[106-126]) | Eukaryota |
Metazoa, Chordata | PrP of Ovis aries |
1.C.48.1.2 | Major prion protein, PrP or PRNP, of 253 aas and 3 possible TMSs, N-terminal, middle, and C-terminal. Its primary physiological function is
unclear. It has cytoprotective activity against internal or environmental
stresses and may play a role in neuronal development and synaptic
plasticity. May be required for neuronal myelin sheath maintenance, but may
play a role in iron uptake and iron homeostasis. Soluble oligomers are
toxic to cultured neuroblastoma cells and induce apoptosis (Mani et al. 2003; Taylor et al. 2009; Wu et al. 2010). The mouse orthologue (P04925), particularly the A116V mutant, forms ion channels in lipid membranes (Sabareesan et al. 2016). It's cell biology has been reviewed (Sarnataro et al. 2017). | Metazoa, Chordata | PrP of Homo sapiens | |
1.C.48.1.3 | Prion protein of 497 aas and 3 TMSs | Metazoa, Chordata | Prion protein of Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) | |
1.C.48.1.4 | Prion-like protein, Doppel (PRND) of 176 aas and 2 TMSs | Metazoa, Chordata | Doppel of Homo sapiens | |
1.C.48.1.5 | Shadow of prion protein, SPRN or SHO, of 151 aas and 3 TMSs | Metazoa, Chordata | SPRN of Homo sapiens |