Dermaseptin S1, Drs1, of 79 aas and 1 or 2 TMSs with the first N-terminal TMS being more hydrophobic than the second C-terminal TMS. The central region is very hydrophilic. It is 90% identical to Dermaseptin B1 (TC# 1.C.52.1.1) at the sequence level. It shows antimicrobial activity with potent activity against Gram-positive and Gram-negative bacteria, fungi and protozoa (Mor et al. 1991, Mor and Nicolas 1994). It also stimulates the microbicidal activity of polymorphonuclear leukocytes (Ammar et al. 1998) and may act by disturbing membrane functions with its amphipathic structure (Mor and Nicolas 1994).
|Species:||Phyllomedusa sauvagei (Sauvage's leaf frog)  |
|Location1 / Topology2 / Orientation3:
1: MDILKKSLFL VLFLGLVSLS ICEEEKRENE DEEKQEDDEQ SEMKRALWKT MLKKLGTMAL
61: HAGKAALGAA ADTISQGTQ