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| Accession Number: | P23631 |
| Protein Name: | Alpha-latrotoxin |
| Length: | 1401 |
| Molecular Weight: | 156857.00 |
| Species: | Latrodectus mactans (Black widow spider) [6925] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Secreted1 |
| Substrate | ion, molecule, inorganic cation |
Cross database links:
| Pfam: | PF00023 |
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Gene Ontology
GO:0016021
C:integral to membrane
GO:0044218
C:other organism cell membrane
GO:0042734
C:presynaptic membrane
GO:0006887
P:exocytosis
GO:0009405
P:pathogenesis
GO:0007268
P:synaptic transmission
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References (7)[1] “Cloning and structure of cDNA encoding alpha-latrotoxin from black widow spider venom.” Kiyatkin N.I.et.al. 1977615 [2] “Alpha-latrotoxin action probed with recombinant toxin: receptors recruit alpha-latrotoxin but do not transduce an exocytotic signal.” Ichtchenko K.et.al. 9799228 [3] “Structure of tryptic fragments of a neurotoxin from black widow spider venom.” Volkova T.M.et.al. 1888339 [4] “Black widow spider toxins: the present and the future.” Grishin E.V.et.al. 9792186 [5] “Tetramerisation of alpha-latrotoxin by divalent cations is responsible for toxin-induced non-vesicular release and contributes to the Ca(2+)-dependent vesicular exocytosis from synaptosomes.” Ashton A.C.et.al. 10865132 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MISVGEIMER ANHSLVRMRR EGEDLTLEEK AEICSELELQ QKYVDIASNI IGDLSSLPIA 61: GKIAGTIAAA AMTATHVASG RLDIEQTLLG CSDLPFDQIK EVLENRFNEI DRKLDSHSAA 121: LEEITKLVEK SISVVEKTRK QMNKRFDEVM KSIQDAKVSP IISKINNFAR YFDTEKERIR 181: GLKLNDYILK LEEPNGILLH FKESRTPTDD SLQAPLFSII EEGYAVPKSI DDELAFKVLY 241: ALLYGTQTYV SVMFFLLEQY SFLANHYYEK GYLEKYDEYF NSLNNVFLDF KSSLVGTGTS 301: NNEGLLDRVL QVLMTVKNSE FLGLEKNGVD EMLNEKINLF NKIKEEIEGK QKMTLSETPE 361: NFAQISFDKD ITTPIGDWRD GREVRYAVQY ASETLFSKIS HWSDPVSVRE KACPTLRMPV 421: DQTRRNVLVF RKFDSSKPQL VGEITPYLSN FIDIDRDLYN AASNPDSAVG FKEFTKLNYD 481: GANIRATFDH GRTVFHAAAK SGNDKIMFGL TFLAKSTELN QPDKKGYTPI HVAADSGNAG 541: IVNLLIQRGV SINSKTYHFL QTPLHLAAQR GFVTTFQRLM ESPEININER DKDGFTPLHY 601: AIRGGERILE AFLNQISIDV NAKSNTGLTP FHLAIIKNDW PVASTLLGSK KVDINAVDEN 661: NITALHYAAI LGYLETTKQL INLKEINANV VSSPGLLSAL HYAILYKHDD VASFLMRSSN 721: VNVNLKALGG ITPLHLAVIQ GRKQILSLMF DIGVNIEQKT DEKYTPLHLA AMSKYPELIQ 781: ILLDQGSNFE AKTNSGATPL HLATFKGKSQ AALILLNNEV NWRDTDENGQ MPIHGAAMTG 841: LLDVAQAIIS IDATVVDIED KNSDTPLNLA AQNSHIDVIK YFIDQGADIN TRNKKGLAPL 901: LAFSKKGNLD MVKYLFDKNA NVYIADNDGM NFFYYAVQNG HLNIVKYAMS EKDKFEWSNT 961: DNNRRDECPN EECAISHFAV CDAVQFDRIE IVKYFVGTLG NFAICGPLHQ AARYGHLDIV 1021: KYLVEEEFLS VDGSKTDTPL CYASENGHFT VVQYLVSNGA KVNHDCGNGM TAIDKAITKN 1081: HLQVVQFLAA NGVDFRRKNS RGTTPFLTAV AENALHIAEY LIREKRQDIN INEQNVDKDT 1141: ALHLAVYYKN LQMIKLLIKY GIDVTIRNAY DKTALDIAID AKFSNIVEYL KTKSGKFRRE 1201: YKSSYGERSL LQTNQISNFI DRKNIEHDHP LFINADNESS ELFSKTASNI DVIGTLLLID 1261: VLIRYFSKQG YISKESDSAS DGITQAAALS ITEKFEDVLN SLHNESAKEQ VDLAEVHGKV 1321: YAALKSGRNS QIHQILCSSL NSISTLKPED MEKLESVIMN SHSSVSLPEV TDSANEAYGE 1381: TLHLFGESCL HSDGILTKKL M