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| Accession Number: | Q02989 |
| Protein Name: | α-LIT |
| Length: | 1411 |
| Molecular Weight: | 157806.00 |
| Species: | Latrodectus mactans (Black widow spider) [6925] |
| Location1 / Topology2 / Orientation3: | Secreted1 |
| Substrate | molecule |
Cross database links:
| Pfam: | PF00023 |
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Gene Ontology
GO:0016021
C:integral to membrane
GO:0044218
C:other organism cell membrane
GO:0042734
C:presynaptic membrane
GO:0006887
P:exocytosis
GO:0009405
P:pathogenesis
GO:0007268
P:synaptic transmission
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References (4)[1] “Cloning and structural analysis of (alpha)-latroinsectotoxin cDNA: abundance of ankyrin-like repeats.” Kiyatkin N.N.I.et.al. 8477689 [2] “Black widow spider toxins: the present and the future.” Grishin E.V.et.al. 9792186 [3] “Tetramerisation of alpha-latrotoxin by divalent cations is responsible for toxin-induced non-vesicular release and contributes to the Ca(2+)-dependent vesicular exocytosis from synaptosomes.” Ashton A.C.et.al. 10865132 [4] “The geometry of the ionic channel lumen formed by alpha-latroinsectotoxin from black widow spider venom in the bilayer lipid membranes.” Shatursky O.Y.et.al. 17764656
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: ACSSPEVSIF HFFVYAGSFV KNFKKMKGSS AISKREMSRA DQCKLLAYTA VGYETVGNVA 61: ADIASIEGAN LVAAPVAAGG HLGKGLTDAA MIAMDCSSIP FEEIKEILNK EFKEMGRKLD 121: KNTEALEHVS KLVSKTLSTV EKIRVEMREG FKLVIETIEN IATKEIVFDI NKIVQYFNNE 181: RENINSRQKE EFVAKLQEPA PGNFLLYLRN SRTSESGTLY SLLFRIIDQE LAIPNNAGDN 241: NAIQALYALF YGTETFISIM FYLVKQYSYL AEYHYQKGNL EEFNTNFDHM KIVFQDFKFS 301: LIGINQNTKP LVDEVLNVLN NVKNKSFIRN VQNKLFYDLM KQTESLLELK KEIANMELPI 361: IDETPRLSIS ISFKERSDDK PVDTPLLKWD KGKEVKYAIQ FEQDGKFSKI SSWSKPVTVQ 421: HLACPFISVD KDRRNRLIFR QFGDQIPELV GTLRGSQVEF RDIHRDLYNA AQVPYAREAL 481: SISRTLIQNG ANVSETFELG RGAIHAAASA GNYDVGELLL NKDINLLEKA DKNGYTPLHI 541: AADSNKNDFV MFLIGNNADV NVRTKSDLFT PLHLAARRDL TDVTQTLIDI TEIDLNAQDK 601: SGFTPLHLSI SSTSETAAIL IRNTNAVINI KSKVGLTPLH LATLQNNLSV SKLLAGKGAY 661: LNDGDANGMT PLHYAAMTGN LEMVDFLLNQ QYININAATK EKKWTPLHLA ILFKKNDVAE 721: RLLSDENLNI RLETNGGINP LHLASATGNK QLVIELLAKN ADVTRLTSKG FSALHLGIIG 781: KNEEIPFFLV EKGANVNDKT NSGVTPLHFA AGLGKANIFR LLLSRGADIK AEDINSQMPI 841: HEAVSNGHLE IVRILIEKDP SLMNVKNIRN EYPFYLAVEK RYKDIFDYFV SKDANVNEVD 901: HNGNTLLHLF SSTGELEVVQ FLMQNGANFR LKNNERKTFF DLAIENGRLN IVAFAVEKNK 961: VNLQAAHRGK TILYHAICDS AKYDKIEIVK YFIEKLNESE CNPLHEAAAY AHLDLVKYFV 1021: QERGINPAEF NEENQASPFC ITIHGAPCGY SLDCDTPDRL EVVEYLSDKI PDINGKCDVQ 1081: ENTPITVAIF ANKVSILNYL VGIGADPNQQ VDGDPPLYIA ARQGRFEIVR CLIEVHKVDI 1141: NTRNKERFTA LHAAARNDFM DVVKYLVRQG ADVNAKGIDD LRPIDIAGEK AKAYLQSSRF 1201: LRSGHSFQSN EIDSFGNTIH GISMSARTND KLTQQISSKG TRSDSNSTEG KMHSENVHVR 1261: SIDVNGALLL LDFMIRVFAS KKTNFAPYGS RIKTRSAAEA QAEALIMTER FENLLSGLIG 1321: DPIPDSIDFS NVHSKIYKAI MSGRRSVISE MLCSFAEEYS KLNHESIKQL LSEFETLTTT 1381: KASEIHIEES VPYAPFEICE LKVNSNVSQI K