1.C.63.1.4
Delta-latroinsectotoxin-Lt1a of 1214 aas and 2 TMSs near the N-terminus. It is an insecticidal presynaptic neurotoxin that induces massive
neurotransmitter release at insect (but not vertebrate) neuromuscular
junctions. Native toxin forms cation-permeable pores (with high
permeability to calcium) in lipid membranes of locust muscle membrane and
artificial lipid bilayers (Chen et al. 2021, Dulubova et al. 1996). It may
bind to insect neurexin-1 homolog, insect adhesion G protein-coupled
receptor L1 homolog, and insect receptor-type tyrosine-protein
phosphatase S homolog, and induces neurotransmitter exocytosis both by
forming tetrameric pores in membranes and signaling via G
protein-coupled receptor. Oligomerization is a process independent of divalent cations (Chen et al. 2021).
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| Accession Number: | Q25338 |
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| Protein Name: | Delta-latroinsectotoxin-Lt1a |
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| Length: | 1214 |
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| Molecular Weight: | 135822.00 |
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| Species: | Latrodectus tredecimguttatus (Mediterranean black widow spider) [6925] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MHSKELQTIS AAVARKAVPN TMVIRLKRDE EDGEMTLEER QAQCKAIEYS NSVFGMIADV
61: ANDIGSIPVI GEVVGIVTAP IAIVSHITSA GLDIASTALD CDDIPFDEIK EILEERFNEI
121: DRKLDKNTAA LEEVSKLVSK TFVTVEKTRN EMNENFKLVL ETIESKEIKS IVFKINDFKK
181: FFEKERQRIK GLPKDRYVAK LLEQKGILGS LKEVREPSGN SLSSALNELL DKNNNYAIPK
241: VVDDNKAFQA LYALFYGTQT YAAVMFFLLE QHSYLADYYY QKGDDVNFNA EFNNVAIIFD
301: DFKSSLTGGD DGLIDNVIEV LNTVKALPFI KNADSKLYRE LVTRTKALET LKNQIKTTDL
361: PLIDDIPETL SQVNFPNDEN QLPTPIGNWV DGVEVRYAVQ YESKGMYSKF SEWSEPFTVQ
421: GNACPTIKVR VDPKKRNRLI FRKFNSGKPQ FAGTMTHSQT NFKDIHRDLY DAALNINKLK
481: AVDEATTLIE KGADIEAKFD NDRSAMHAVA YRGNNKIALR FLLKNQSIDI ELKDKNGFTP
541: LHIAAEAGQA GFVKLLINHG ADVNAKTSKT NLTPLHLATR SGFSKTVRNL LESPNIKVNE
601: KEDDGFTPLH TAVMSTYMVV DALLNHPDID KNAQSTSGLT PFHLAIINES QEVAESLVES
661: NADLNIQDVN HMAPIHFAAS MGSIKMLRYL ISIKDKVSIN SVTENNNWTP LHFAIYFKKE
721: DAAKELLKQD DINLTIVADG NLTVLHLAVS TGQINIIKEL LKRGSNIEEK TGEGYTSLHI
781: AAMRKEPEIA VVLIENGADI EARSADNLTP LHSAAKIGRK STVLYLLEKG ADIGAKTADG
841: STALHLAVSG RKMKTVETLL NKGANLKEYD NNKYLPIHKA IINDDLDMVR LFLEKDPSLK
901: DDETEEGRTS IMLIVQKLLL ELYNYFINNY AETLDEEALF NRLDEQGKLE LAYIFHNKEG
961: DAKEAVKPTI LVTIKLMEYC LKKLREESGA PEGSFDSPSS KQCISTFSED EMFRRTLPEI
1021: VKETNSRYLP LKGFSRSLNK FLPSLKFAES KNSYRSENFV SNIDSNGALL LLDVFIRKFT
1081: NEKYNLTGKE AVPYLEAKAS SLRIASKFEE LLTEVKGIPA GELINMAEVS SNIHKAIASG
1141: KPVSKVLCSY LDTFSELNSQ QMEELVNTYL STKPSVITSA SADYQKLPNL LTATCLEPER
1201: MAQLIDVHQK MFLR