1.C.73.1.2
The cholix toxin. The NAD-dependent ADP-ribosyltransferase
(ADPRT) catalyzes transfer of the ADP-ribosyl moiety of oxidized
NAD onto eukaryotic elongation factor 2 (eEF-2), thus arresting protein
synthesis. It may use the eukaryotic pro-low-density lipoprotein
receptor-related protein 1 (LRP1) to enter mouse cells, Cholix toxin shares structural and functional properties with Pseudomonas aeruginosa exotoxin A and Corynebacterium diphtheriae diphtheria toxin (Lugo and Merrill 2015).
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| Accession Number: | Q5EK40 |
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| Protein Name: | Cholix toxin |
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| Length: | 666 |
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| Molecular Weight: | 74293.00 |
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| Species: | Vibrio cholerae [666] |
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| Number of TMSs: | 1 |
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| Substrate |
toxin |
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1: MYLTFYLEKV MKKMLLIAGA TVISSMAHPT FAVEDELNIF DECRSPCSLT PEPGKPIQSK
61: LSIPSDVVLD EGVLYYSMTI NDEQNDIKDE DKGESIITIG EFATVRATRH YVNQDAPFGV
121: IHLDITTENG TKTYSYNRKE GEFAINWLVP IGEDSPASIK ISVDELDQQR NIIEVPKLYS
181: IDLDNQTLEQ WKTQGNVSFS VTRPEHNIAI SWPSVSYKAA QKEGSRHKRW AHWHTGLALC
241: WLVPMDAIYN YITQQNCTLG DNWFGGSYET VAGTPKVITV KQGIEQKPVE QRIHFSKGNA
301: MSALAAHRVC GVPLETLARS RKPRDLTDDL SCAYQAQNIV SLFVATRILF SHLDSVFTLN
361: LDEQEPEVAE RLSDLRRINE NNPGMVTQVL TVARQIYNDY VTHHPGLTPE QTSAGAQAAD
421: ILSLFCPDAD KSCVASNNDQ ANINIESRSG RSYLPENRAV ITPQGVTNWT YQELEATHQA
481: LTREGYVFVG YHGTNHVAAQ TIVNRIAPVP RGNNTENEEK WGGLYVATHA EVAHGYARIK
541: EGTGEYGLPT RAERDARGVM LRVYIPRASL ERFYRTNTPL ENAEEHITQV IGHSLPLRNE
601: AFTGPESAGG EDETVIGWDM AIHAVAIPST IPGNAYEELA IDEEAVAKEQ SISTKPPYKE
661: RKDELK