α-synuclein (140 aas). In addition to β-amyloid, the cellular prion protein, PrP^C  binds α-synuclein, which is responsible for neurodegenerative synucleopathies (Urrea et al. 2017). β-barrel channels such as α-hemolysin may serve as sensitive probes of α-synuclein (α-syn) interactions with membranes as well as model systems for studies of channel-assisted protein transport (Gurnev et al. 2014).  α-synuclein interacts with membranes to affect Ca²⁺ signalling, and the oligomeric β-sheet-rich α-synuclein leads to Ca²⁺ dysregulation and Ca²⁺-dependent cell death (Angelova et al. 2016).