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| Accession Number: | P10845 |
| Protein Name: | BXA aka BOTA aka BNA aka ATX |
| Length: | 1296 |
| Molecular Weight: | 149454.00 |
| Species: | Clostridium botulinum [1491] |
| Location1 / Topology2 / Orientation3: | Secreted1 / Multi-pass membrane protein2 |
| Substrate | peptide |
Cross database links:
| Pfam: | PF01742 PF07951 PF07953 PF07952 |
|---|---|
Gene Ontology
GO:0005829
C:cytosol
GO:0030666
C:endocytic vesicle membrane
GO:0044164
C:host cell cytosol
GO:0044156
C:host cell junction
GO:0044231
C:host cell presynaptic membrane
GO:0016021
C:integral to membrane
GO:0004222
F:metalloendopeptidase activity
GO:0050827
F:toxin receptor binding
GO:0008270
F:zinc ion binding
GO:0051609
P:inhibition of neurotransmitter uptake
GO:0009405
P:pathogenesis
GO:0006508
P:proteolysis
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References (12)[1] “The complete amino acid sequence of the Clostridium botulinum type A neurotoxin, deduced by nucleotide sequence analysis of the encoding gene.” Thompson D.E.et.al. 2185020 [2] “The complete sequence of botulinum neurotoxin type A and comparison with other clostridial neurotoxins.” Binz T.et.al. 2160960 [3] “Organization and phylogenetic interrelationships of genes encoding components of the botulinum toxin complex in proteolytic Clostridium botulinum types A, B, and F: evidence of chimeric sequences in the gene encoding the nontoxic nonhemagglutinin component.” East A.K.et.al. 8863443 [4] “Molecular characterization of two forms of nontoxic-nonhemagglutinin components of Clostridium botulinum type A progenitor toxins.” Fujita R.et.al. 8521962 [5] “Partial amino acid sequence of the heavy and light chains of botulinum neurotoxin type A.” Schmidt J.J.et.al. 6370252 [6] “Botulinum neurotoxin type A: sequence of amino acids at the N-terminus and around the nicking site.” Dasgupta B.R.et.al. 2126206 [7] “Botulinum neurotoxin type A: cleavage of the heavy chain into two halves and their partial sequences.” Sathymoorthy V.et.al. 3178218 [8] “Inactivation of Clostridium botulinum type A neurotoxin by trypsin and purification of two tryptic fragments. Proteolytic action near the COOH-terminus of the heavy subunit destroys toxin-binding activity.” Shone C.C.et.al. 3896784 | |
| Structure: | |
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MPFVNKQFNY KDPVNGVDIA YIKIPNVGQM QPVKAFKIHN KIWVIPERDT FTNPEEGDLN 61: PPPEAKQVPV SYYDSTYLST DNEKDNYLKG VTKLFERIYS TDLGRMLLTS IVRGIPFWGG 121: STIDTELKVI DTNCINVIQP DGSYRSEELN LVIIGPSADI IQFECKSFGH EVLNLTRNGY 181: GSTQYIRFSP DFTFGFEESL EVDTNPLLGA GKFATDPAVT LAHELIHAGH RLYGIAINPN 241: RVFKVNTNAY YEMSGLEVSF EELRTFGGHD AKFIDSLQEN EFRLYYYNKF KDIASTLNKA 301: KSIVGTTASL QYMKNVFKEK YLLSEDTSGK FSVDKLKFDK LYKMLTEIYT EDNFVKFFKV 361: LNRKTYLNFD KAVFKINIVP KVNYTIYDGF NLRNTNLAAN FNGQNTEINN MNFTKLKNFT 421: GLFEFYKLLC VRGIITSKTK SLDKGYNKAL NDLCIKVNNW DLFFSPSEDN FTNDLNKGEE 481: ITSDTNIEAA EENISLDLIQ QYYLTFNFDN EPENISIENL SSDIIGQLEL MPNIERFPNG 541: KKYELDKYTM FHYLRAQEFE HGKSRIALTN SVNEALLNPS RVYTFFSSDY VKKVNKATEA 601: AMFLGWVEQL VYDFTDETSE VSTTDKIADI TIIIPYIGPA LNIGNMLYKD DFVGALIFSG 661: AVILLEFIPE IAIPVLGTFA LVSYIANKVL TVQTIDNALS KRNEKWDEVY KYIVTNWLAK 721: VNTQIDLIRK KMKEALENQA EATKAIINYQ YNQYTEEEKN NINFNIDDLS SKLNESINKA 781: MININKFLNQ CSVSYLMNSM IPYGVKRLED FDASLKDALL KYIYDNRGTL IGQVDRLKDK 841: VNNTLSTDIP FQLSKYVDNQ RLLSTFTEYI KNIINTSILN LRYESNHLID LSRYASKINI 901: GSKVNFDPID KNQIQLFNLE SSKIEVILKN AIVYNSMYEN FSTSFWIRIP KYFNSISLNN 961: EYTIINCMEN NSGWKVSLNY GEIIWTLQDT QEIKQRVVFK YSQMINISDY INRWIFVTIT 1021: NNRLNNSKIY INGRLIDQKP ISNLGNIHAS NNIMFKLDGC RDTHRYIWIK YFNLFDKELN 1081: EKEIKDLYDN QSNSGILKDF WGDYLQYDKP YYMLNLYDPN KYVDVNNVGI RGYMYLKGPR 1141: GSVMTTNIYL NSSLYRGTKF IIKKYASGNK DNIVRNNDRV YINVVVKNKE YRLATNASQA 1201: GVEKILSALE IPDVGNLSQV VVMKSKNDQG ITNKCKMNLQ DNNGNDIGFI GFHQFNNIAK 1261: LVASNWYNRQ IERSSRTLGC SWEFIPVDDG WGERPL