1.C.81.2.2
Integral membrane protein, Itm2A, of 263 aas and 1 vey hydrophobic TMS near the N-terminus, plus 3 moderately hydrophobic putative TMSs near the C-terminus of the protein. Constitutive overexpression of Itm2A enhances myogenic differentiation (Van den Plas and Merregaert 2004). Antibodies against ITM2A are internalized in ITM2A-overexpressing HEK293 cells, and ITM2A is expressed in brain microvessels (Cegarra et al. 2022).
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| Accession Number: | O43736 |
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| Protein Name: | Integral membrane protein 2A |
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| Length: | 263 |
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| Molecular Weight: | 29741.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type II membrane protein2 |
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| Substrate |
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1: MVKIAFNTPT AVQKEEARQD VEALLSRTVR TQILTGKELR VATQEKEGSS GRCMLTLLGL
61: SFILAGLIVG GACIYKYFMP KSTIYRGEMC FFDSEDPANS LRGGEPNFLP VTEEADIRED
121: DNIAIIDVPV PSFSDSDPAA IIHDFEKGMT AYLDLLLGNC YLMPLNTSIV MPPKNLVELF
181: GKLASGRYLP QTYVVREDLV AVEEIRDVSN LGIFIYQLCN NRKSFRLRRR DLLLGFNKRA
241: IDKCWKIRHF PNEFIVETKI CQE