1.C.81.2.3
Integral membrane protein 2C, Itm2C (BRI3, Hucep-14, NPD018), of 267 aas with 1 strongly hydrophobic TMS near the N-terminus. It is a negative regulator of amyloid-beta peptide
production, and may inhibit the processing of APP by blocking its access to
alpha- and beta-secretase (Gong et al. 2008). Binding to the beta-secretase-cleaved APP
C-terminal fragment is negligible, suggesting that ITM2C is a poor
gamma-secretase cleavage inhibitor. It may also play a role in TNF-induced cell
death and neuronal differentiation (Matsuda et al. 2009).
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| Accession Number: | Q9NQX7 |
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| Protein Name: | Integral membrane protein 2C |
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| Length: | 267 |
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| Molecular Weight: | 30224.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Lysosome membrane1 / Single-pass type II membrane protein2 |
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| Substrate |
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1: MVKISFQPAV AGIKGDKADK ASASAPAPAS ATEILLTPAR EEQPPQHRSK RGGSVGGVCY
61: LSMGMVVLLM GLVFASVYIY RYFFLAQLAR DNFFRCGVLY EDSLSSQVRT QMELEEDVKI
121: YLDENYERIN VPVPQFGGGD PADIIHDFQR GLTAYHDISL DKCYVIELNT TIVLPPRNFW
181: ELLMNVKRGT YLPQTYIIQE EMVVTEHVSD KEALGSFIYH LCNGKDTYRL RRRATRRRIN
241: KRGAKNCNAI RHFENTFVVE TLICGVV