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|---|---|
| Accession Number: | P60022 |
| Protein Name: | β-defensin-1 |
| Length: | 68 |
| Molecular Weight: | 7420.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Secreted1 |
| Substrate | molecule |
Cross database links:
| RefSeq: | NP_005209.1 |
|---|---|
| Entrez Gene ID: | 1672 |
| Pfam: | PF00711 |
| OMIM: |
602056 gene |
| KEGG: | hsa:1672 |
Gene Ontology
GO:0005576
C:extracellular region
GO:0006935
P:chemotaxis
GO:0042742
P:defense response to bacterium
GO:0007186
P:G-protein coupled receptor protein signalin...
GO:0045087
P:innate immune response
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References (7)[1] “The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry.” Liu L.et.al. 9268634 [2] “Human airway epithelia express a beta-defensin.” McCray P.B. Jr.et.al. 9070620 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “hBD-1: a novel beta-defensin from human plasma.” Bensch K.W.et.al. 7628632 [5] “Chemical synthesis of beta-defensins and LEAP-1/hepcidin.” Kluever E.et.al. 12010514 [6] “The structure of human beta-defensin-1: new insights into structural properties of beta-defensins.” Hoover D.M.et.al. 11486002 [7] “Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity.” Bauer F.et.al. 11714914
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| Structure: | |
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1: MRTSYLLLFT LCLLLSEMAS GGNFLTGLGH RSDHYNCVSS GGQCLYSACP IFTKIQGTCY 61: RGKAKCCK