1.C.85.2.2
Crotamine-IV-2 toxin of 42 aas and 0 TMSs. Croamines are cationic peptides that possess multiple functions. hey act as cell-penetrating peptides (CPPs), as potent voltage-gated potassium channel inhibitors and as antimicrobial agents (Hayashi et al. 2008). As an antimicrobial peptide, crotamine shows antibacterial activity against E.coli and B.subtilis, and antifungal activity against Candida spp., Trichosporon spp. and C. neoformans. It kills bacteria through membrane permeabilization (Hayashi et al. 2008). It selectively inhibits Kv1.1/KCNA1, Kv1.2/KCNA2 and Kv1.3/KCNA3 channels (Peigneur et al. 2012). It is also hemolytic (Oguiura et al. 2011).