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1.C.95.1.1 Pore-forming ESAT-6 (EsxA) (95 aas) (Nuñez-Garcia et al. 2018). Secreted from the bacterial cytoplasm via a ESX protein secretion system (Type VII; TC# 3.A.24.5.1).
Accession Number:	P0A564
Protein Name:	Rv3875 (esat-6)
Length:	95
Molecular Weight:	9904.00
Species:	Mycobacterium tuberculosis [1773]
Location¹ / Topology² / Orientation³:	Secreted¹
Substrate	molecule

Structure:
RefSeq:	NP_338543.1 YP_178023.1
Entrez Gene ID:	886209 922546
KEGG:	mtc:MT3989 mtu:Rv3875
Gene Ontology GO:0005576 C:extracellular region GO:0005515 F:protein binding
References (10) [1] “Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice.” Andersen P.et.al. 7897219 [2] “Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis.” Soerensen A.L.et.al. 7729876 [3] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.” Cole S.T.et.al. 9634230 [4] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.” Fleischmann R.D.et.al. 12218036 [5] “A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10).” Berthet F.-X.et.al. 9846755 [6] “Conclusive evidence that the major T-cell antigens of the Mycobacterium tuberculosis complex ESAT-6 and CFP-10 form a tight, 1:1 complex and characterization of the structural properties of ESAT-6, CFP-10, and the ESAT-6*CFP-10 complex. Implications for pathogenesis and virulence.” Renshaw P.S.et.al. 11940590 [7] “Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system.” Stanley S.A.et.al. 14557536 [8] “Mutually dependent secretion of proteins required for mycobacterial virulence.” Fortune S.M.et.al. 16030141 [9] “Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.” Brodin P.et.al. 16368961 [10] “ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria.” DiGiuseppe Champion P.A.et.al. 19682254
1WA8 3FAV

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MTEQQWNFAG IEAAASAIQG NVTSIHSLLD EGKQSLTKLA AAWGGSGSEA YQGVQQKWDA 
61:	TATELNNALQ NLARTISEAG QAMASTEGNV TGMFA

1.C.95.1.1
Pore-forming ESAT-6 (EsxA) (95 aas) (Nuñez-Garcia et al. 2018). Secreted from the bacterial cytoplasm via a ESX protein secretion system (Type VII; TC# 3.A.24.5.1).

Cross database links:

Gene Ontology

References (10)

External Searches:

Analyze:

1.C.95.1.1Pore-forming ESAT-6 (EsxA) (95 aas) (Nuñez-Garcia et al. 2018). Secreted from the bacterial cytoplasm via a ESX protein secretion system (Type VII; TC# 3.A.24.5.1).

Cross database links:

Gene Ontology

References (10)

External Searches:

Analyze:

1.C.95.1.1
Pore-forming ESAT-6 (EsxA) (95 aas) (Nuñez-Garcia et al. 2018). Secreted from the bacterial cytoplasm via a ESX protein secretion system (Type VII; TC# 3.A.24.5.1).