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1.D.124.  The Cell-Permeable Myristoylated Synthetic Peptide, TMEM39AS41 (TMEM39AS41) Family 

Transmembrane protein (TMEM) 39AS41, a synthetic peptide, was generated from the protein kinase B substrate motif 34GLRNRNGSAIGLPVP48 found in the human TMEM39A protein (TC# 9.B.385.1.1). Myristic acid was conjugated to the N-terminus of the peptide to confer cell permeability. Park et al. 2020 found that in vitro, the TMEM39AS41 peptide led to cell death via inhibition of inflammation/autophagy pathways in KRAS-mutated cell and tissues. At a dose of 30 mg/kg, it significantly suppressed tumor growth in KRASLA1 non-small cell lung cancer mice. These results suggest that this peptide may have therapeutic potential for lung cancer.

References associated with 1.D.124 family:

Park, S., M. Kim, Y. Hong, H. Lee, Q. Tran, C. Kim, S.H. Kwon, J. Park, J. Park, and S.H. Kim. (2020). Myristoylated TMEM39AS41, a cell-permeable peptide, causes lung cancer cell death. Toxicol Res 36: 123-130. 32257924