TCDB is operated by the Saier Lab Bioinformatics Group

1.D.152.  The Dihydrazide/Dialdehyde Anion Nanochannel (DDA-NC) Family

Anion transmembrane nanochannels constructed from dynamic covalent helices (DCHs) have been developed (Zhang et al. 2021). The dynamic covalent structures can be synthesized by one-pot dynamic covalent reactions and helically self-fold into nanotubes through intramolecular hydrogen bonding and pi-pi interactions. Such helical structures can vertically self-assemble into long nanofibers under pi-pi stacking, and their hollow nanocavities form ion permeation pathways across lipid membranes. Single-channel electrophysiological signals provided solid evidence of DCHs following a channel rather than a carrier mechanism. Owing to the pore-forming capacity of DCHs, nanochannels are able to accelerate the movement of anions across lipid membranes with high transport activity (EC50 =0.08 mol %). Moreover, DCH channels show dehydration energy dependent anion selectivity. Such DCHs can be considered to be general channel scaffolds with economical synthesis and special nanocavities (Zhang et al. 2021).

References associated with 1.D.152 family:

Zhang, C., J. Zhang, W. Li, S. Mao, and Z. Dong. (2021). Anion Transmembrane Nanochannels from Pore-Forming Helices Constructed by the Dynamic Covalent Reaction of Dihydrazide and Dialdehyde Units. Chempluschem 86: 492-495. 33733612