1.D.228.  The Self-assembled Water-transporting Peptide-bound Ni²⁺ Metallomacrocycle (SWP-NM) Family 

Self-assembled peptide-bound Ni²⁺ metallomacrocycles, in which rim-peptide-bound units are connected to a central macrocycle obtained via condensation in the presence of Ni²⁺ ions have been constructed (Huang et al. 2023). Compound 1 (see below)  achieves a single-channel permeability up to 10⁷-10⁸ water molecules/channel with insignificant ion transport at rates that are about one order of magnitude lower than those for aquaporins. Molecular simulations suggest that spongelike aggregates can form to generate transient cluster water pathways through the bilayer. Altogether, adaptive metallosupramolecular self-assembly is an efficient and simple way to construct selective channel superstructures (Huang et al. 2023).