1.D.237. The Bispidine Scafford Transporter (BST) Family
The development of designer topological structures is a synthetically challenging endeavor. Singh et al. 2023 presented bispidine as a platform for the design of molecules with various topologies and functions. Bispidine-based acyclic molecules show S-shape topologies. Single crystal X-ray analyses revealed that this molecules exist in the solid state as two conformational enantiomers. Bispidine-based designer macrocycles were synthesized and investigated for their ionophoric properties. Patch clamp experiments revealed that these macrocycles transport non-specifically both anions and cations with at least a 10-fold higher chloride conductance over cations under the given experimental conditions. The results indicated that the self-assembling macrocycles form tubular assemblies. This work highlights the utility of non-conventional dihydrogen interactions in nanotube fabrication (Singh et al. 2023).