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1.D.237.  The Bispidine Scafford Transporter (BST) Family 

The development of designer topological structures is a synthetically challenging endeavor. Singh et al. 2023 presented bispidine as a platform for the design of molecules with various topologies and functions. Bispidine-based acyclic molecules show S-shape topologies.  Single crystal X-ray analyses revealed that this molecules exist in the solid state as two conformational enantiomers. Bispidine-based designer macrocycles were synthesized and investigated for their ionophoric properties. Patch clamp experiments revealed that these macrocycles transport non-specifically both anions and cations with at least a 10-fold higher chloride conductance over cations under the given experimental conditions. The results indicated that the self-assembling macrocycles form tubular assemblies. This work highlights the utility of non-conventional dihydrogen interactions in nanotube fabrication (Singh et al. 2023).

References associated with 1.D.237 family:

Singh, H., N. Khatoon, S.K. Bhardwaj, P. Kampani, T.K. Nayak, and V. Haridas. (2023). Bispidine as a versatile scaffold: From topological hosts to transmembrane transporters. Chembiochem e202300502. [Epub: Ahead of Print] 37708237