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1.D.243.  The Soy Protein NanoParticle (SPNP) Family. 

Enhanced curcumin transport across epithelial barriers by mucus-permeable soy protein nanoparticles has been reported to be mediated by dual transcytosis pathways.  Nanocarrier-delivered bioactive compounds are desirable because of their improved stability and applicability, but their bioavailability is limited due to strong mucus and epithelial cell barriers. A series of self-assembled soy protein nanoparticles (SPNPs) with different mucus permeabilities were prepared, and their delivery efficiency upon Curcumin (Cur) encapsulation was evaluated (Yuan et al. 2024). The formed SPNPs-Cur exhibited high compatibility and cellular antioxidant accessibility. SPNPs enhanced the cellular uptake and transmembrane permeation of Cur, and this especially promoted the transport of proto-Cur in addition to Cur metabolites. The SPNPs with the rapid mucus diffusion capacity presented more efficient transcytosis across the Caco-2 cell monolayer, which was mediated by a combination of paracellular and transcellular pathways. Thus, mucus-permeable soy protein nanoparticles provide a promising delivery system for improving the bioavailability of bioactive compounds such as curcumin..


References associated with 1.D.243 family:

Yuan, D., Q. Li, Q. Zhang, F. Zhou, Q. Zhao, and M. Zhao. (2024). Enhanced curcumin transportation across epithelial barrier by mucus-permeable soy protein nanoparticles-mediated dual transcytosis pathways. Food Chem 437: 137771. 37897825