1.D.256. Supramolecular Channels in Gap Junctions (SC-GJ) Family
Tubular structures exist broadly in biological systems and exhibit important functions including mediating cellular communication. The construction of artificial analogues in living cells could provide a new strategy for chemotherapy. Xiao et al. 2024 constructed a kind of supramolecular channel within intercellular gaps by mimicking the assembly process and structure of natural gap junctional channels, which consist of hydrophobic tubular modules located in the adjacent cell membranes and hydrophilic modules within the extracellular space. The assembly of these channels was driven by electrostatic interactions. The channels could inhibit tumor cell invasion by preventing cell migration.